tigecycline, Tygacil (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Tigecycline also is used for treating community-acquired bacterial pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, and Legionella pneumophila. To prevent resistance, tigecycline should only be used to treat infections caused or very likely to be caused by susceptible strains of bacteria.
Other side effects include:
Tigecycline is similar to tetracycline antibiotics and therefore may have similar side effects such as increased sensitivity to sunlight. Tigecycline may cause permanent discoloration of teeth if used during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years). Like other antibiotics, tygecycline can alter normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile, which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting tigecycline (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.
GENERIC AVAILABLE: No.
PREPARATIONS: Single dose vial: 50 mg
STORAGE: The powder should be stored at room temperature between 15 C - 30 C (59 F - 86 F). Once mixed, it may be stored at room temperature for up to 24 hours (up to six hours in the vial and the remaining time in the intravenous bag). It may also be refrigerated at 2 C - 8 C (36 F - 46 F) for up to 48 hours in an intravenous bag after mixing.
Medically Reviewed by a Doctor on 3/30/2015
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