tigecycline, Tygacil

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GENERIC NAME: tigecycline


DRUG CLASS AND MECHANISM: Tigecycline is an injectable antibiotic used for the treatment of infections caused by susceptible bacteria. Tigecycline is similar to tetracycline antibiotics and has activity against a large number of bacteria. Tigecycline binds to bacterial ribosomes which produce the cell's proteins. The binding prevents bacterial ribosomes from producing important proteins needed for bacterial growth and multiplication. Tigecycline prevents bacteria from multiplying, but it does not kill bacteria. Tigecycline was approved by the FDA in June 2005.



PREPARATIONS: Single dose vial: 50 mg

STORAGE: The powder should be stored at room temperature between 15-30 C (59-86 F). Once mixed, it may be stored at room temperature for up to 24 hours (up to six hours in the vial and the remaining time in the intravenous bag). It may also be refrigerated at 2-8 C (36-46 F) for up to 48 hours in an intravenous bag after mixing.

PRESCRIBED FOR: Tigecycline is used for the treatment of complicated skin infections caused by susceptible strains of bacteria including Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus anginosus group, Streptococcus pyogenes and Bacteroides fragilis.

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