SIDE EFFECTS: Common side effects of ticlopidine include:
Ticlopidine has been associated with a severe reduction in white blood cell count. Ticlopidine also causes a condition called thrombotic thrombocytopenic purpura (TTP). TTP is a serious condition in which blood clots form throughout the body. Blood platelets, which participate in clotting, are consumed, and the result can be bleeding because enough platelets are no longer left to allow blood to clot normally.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 250 mg
STORAGE: Ticlopidine should be stored at room temperature, 15 to 30 C (59 to 86 F).
DOSING: The recommended dose is 250 mg twice daily with food for stroke prevention. For preventing blood clots in stents, a single 500 mg loading dose is administered several hours before stent placement, and then 250 mg is administered twice daily for 10-14 days after successful stent placement.
DRUG INTERACTIONS: Combining ticlopidine with other drugs that promote bleeding increases the risk of bleeding. Examples include aspirin, warfarin (Coumadin), and heparin. Ticlopidine may increase duloxetine (Cymbalta) levels by reducing the break down of duloxetine in the liver and thereby lead to side effects from duloxetine. The combination may also increase the risk of bleeding because duloxetine can interfere with platelet function. Ticlopidine may increase pimozide (Orap) levels by reducing the break-down of pimozide in the liver. Increased pimozide levels may cause abnormal heart rhythms.
PREGNANCY: Ticlopidine has not been adequately studied in pregnant women.
NURSING MOTHERS: It is not known if ticlopidine is secreted in human breast milk.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
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