ticlopidine, Ticlid (discontinued brand in the US) (cont.)

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Medical and Pharmacy Editor:

PRESCRIBED FOR: Ticlopidine is used for preventing strokes in patients who have a history of stroke or transient ischemic attacks (TIAs or "mini-stroke"). It also is used for preventing blood clots in stents placed in the arteries of the heart. Non-FDA approved (off-label) uses include prevention of heart attacks in patients with unstable angina (that often precedes heart attacks) or who have experienced prior heart attacks; in combination with aspirin for preventing blood clots in stents; and for intermittent claudication (due to blockage by clots of blood flowing to the legs). Ticlopidine is most often used when aspirin has failed, is not tolerated, or cannot be used for other reasons. It is rarely used otherwise because of a serious side effect that can reduce white blood cells and platelets.

SIDE EFFECTS: Common side effects of ticlopidine include:

Ticlopidine has been associated with a severe reduction in white blood cell count. Ticlopidine also causes a condition called thrombotic thrombocytopenic purpura (TTP). TTP is a serious condition in which blood clots form throughout the body. Blood platelets, which participate in clotting, are consumed, and the result can be bleeding because enough platelets are no longer left to allow blood to clot normally.



PREPARATIONS: Tablets: 250 mg

STORAGE: Ticlopidine should be stored at room temperature, 15 to 30 C (59 to 86 F).

DOSING: The recommended dose is 250 mg twice daily with food for stroke prevention. For preventing blood clots in stents, a single 500 mg loading dose is administered several hours before stent placement, and then 250 mg is administered twice daily for 10-14 days after successful stent placement.

Medically Reviewed by a Doctor on 5/22/2015

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