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Medication Written by Pharmacists Reviewed by Doctors

GENERIC NAME: ticlopidine

BRAND NAME: Ticlid

DRUG CLASS AND MECHANISM: Ticlopidine interferes with platelet membrane function. Platelets work in the body by helping in the formation of blood clots. If platelets do not function properly, the blood becomes "thinner" and does not clot normally. Thinner blood reduces the risk of thromboses (blood clots in vessels).

A stroke occurs when a clot forms in a blood vessel in the brain (thrombus) or forms in another part of the body and breaks off, then travels to the brain (an embolus). In both cases the blood supply to part of the brain is blocked and that part of the brain is damaged. Ticlopidine works by making the blood less likely to clot, thus, less likely to have a stroke.

PRESCRIPTION: yes

GENERIC AVAILABLE: no

PREPARATIONS: 250mg oral tablets.

STORAGE: Store in a dry place at 15-30 degrees C (59- 86 F).

PRESCRIBED FOR: Ticlopidine is used in the reduction of risk for strokes. Ticlopidine is indicated for people who cannot take aspirin. Ticlopidine is only used for patients with a risk for stroke.

DOSING: Ticlopidine should be taken at doses specifically directed by the physician. Over use can lead bleeding and a fall in your white cell count. Blood testing may be used to monitor for side effects. Patients should maintain follow-up appointments for blood tests and report to the doctor any sign of increase infection, bruising, or bleeding while taking and two weeks after stopping ticlopidine.

DRUG INTERACTIONS: Ticlopidine should not be taken by patients with bleeding tendencies, such as bleeding ulcers or those taking anticoagulants without consulting the physician. Ticlopidine is used with caution in patients with liver disease. Ticlopidine can cause elevation of cholesterol and triglycerides.

Frequently ticlopidine is stopped a week or two before surgery. Ticlopidine interacts with a variety of drugs, so patients taking other medications should consult their pharmacists.

PREGNANCY: Ticlopidine should not be used if pregnant.

NURSING MOTHERS: Ticlopidine should not be used if breast feeding.

SIDE EFFECTS: Ticlopidine can occasionally cause diarrhea, rash, nausea, "acid" stomach, and vomiting.






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Last Editorial Review: 12/31/1997





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