DRUG INTERACTIONS: Combining thioridazine with medications such as procainamide (Pronestyl), sotalol (Betapace), amiodarone (Cordarone), and dofetilide (Tikosyn) that affect heart rate and rhythm can cause abnormal heart beats.
Antidepressants such as fluoxetine (Prozac), sertraline (Zoloft) and tricyclic antidepressants may reduce the breakdown of thioridazine, leading to increased blood levels and side effects of thioridazine.
Thioridazine should be used with caution with medications that depress the central nervous system and cause sedation or drowsiness. Examples include alprazolam (Xanax), clonazepam (Klonopin), zolpidem (Ambien), codeine, morphine, and alcohol. Such combinations can cause excessive sedation, drowsiness, weakness, confusion, speech impairment, and in severe cases coma or death. Combining alcohol with thioridazine also increases the risk of low blood pressure.
PREGNANCY: Use of thioridazine during pregnancy has not been adequately studied. Infants exposed to antipsychotics during the third trimester of pregnancy are at risk for extrapyramidal and withdrawal symptoms after birth. Symptoms reported included agitation, hypertonia, hypotonia, tremor, somnolence, depressed breathing, and feeding disorder.
NURSING MOTHERS: Safe use of thioridazine by nursing mothers has not been established.
REFERENCE: FDA Prescribing Information.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.