thioridazine (Mellaril is a discontinued brand)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: thioridazine
DISCONTINUED BRAND (S): Mellaril
DRUG CLASS AND MECHANISM: Thioridazine is an oral antipsychotic medication used for the management of schizophrenia. Thioridazine is one of the older, first-generation antipsychotic medications. Examples of other first-generation antipsychotics include:
Although the exact mechanism of antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another. Thioridazine is used when patients do not respond to other antipsychotics.
PRESCRIBED FOR: Thioridazine is used for the management of schizophrenia and depressive disorders.
SIDE EFFECTS WARNING:
Long-term use of thioridazine may lead to a potentially irreversible condition called tardive dyskinesia (involuntary movements of the jaw, lips, and tongue).
A potentially fatal complex referred to as neuroleptic malignant syndrome has been reported with anti-psychotic drugs, including thioridazine. Patients who develop this syndrome may have
Tardive dyskinesia and neuroleptic malignant syndrome can result from thioridazine treatment. These side effects can be severe, and require medical help. Neuroleptic malignant syndrome is a medical emergency.
Other serious side effects and adverse reactions include
Medically Reviewed by a Doctor on 11/6/2015
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