thiazide w/spironolactone-oral (cont.)

HOW TO USE: Take this exactly as prescribed. Do not skip doses or increase the dose without your doctor's approval. Take with food or milk to minimize stomach upset. Because this drug may increase urination, avoid taking a dose late in the day.

SIDE EFFECTS: This drug may cause dizziness or blurred vision. Use caution engaging in activities requiring alertness. Watch for signs of dehydration such as dry mouth or thirst. You may experience nausea, vomiting, loss of appetite, fatigue, sleeplessness, or nasal congestion the first few days as your body adjusts to the medication. If these effects persist or become bothersome, inform your doctor. Because this drug changes your fluid balance, you may feel dizzy if you change from a lying to a standing position too rapidly. Avoid this by sitting up a few minutes before rising. Thiazide-containing diuretics increase sensitivity to sunlight. Notify your doctor if you develop: a skin rash, yellowing of the skin, deepening of the voice, sore throat, weakness, irregular pulse, change in amount of urine, persistent cough. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: gout, diabetes, liver problems. Tell your doctor if you are allergic to sulfa drugs. You may also be allergic to this medication. Thiazides can make you more prone to sunburn. Avoid prolonged sun exposure. Use a sunscreen and wear protective clothing. Alcohol may further lower your blood pressure. Ask your doctor about its use. This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: This drug is not recommended for use with: dofetilide. Ask your doctor or pharmacist for more details. Inform your doctor about all the medicines you use (both prescription and nonprescription) especially of: ACE inhibitors (e.g., captopril), lithium, digoxin, NSAID (e.g., ibuprofen, naproxen, aspirin). If you take colestipol or cholestyramine, take the diuretic 1 hour before or 4 hours after the cholesterol lowering medicine because of decreased absorption. Do not start or stop any medicine without doctor or pharmacist approval.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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