theophylline, Respbid, Slo-Bid, Theo-24, (Theolair, Uniphyl Theo-Dur, and Slo-Phyllin-discontinued) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Theophylline toxicity can cause nausea, vomiting, insomnia, seizures, agitation and life- threatening heart rhythm abnormalities. St. John's Wort, rifampin, and carbamazepine decrease levels of theophylline and potentially its effect by increasing its elimination. Theophylline may decrease levels and the effect of carbamazepine by increasing its elimination. Theophylline is metabolized mainly by the liver and dosages should be reduced in patients with liver dysfunction. On the other hand, theophylline is generally metabolized more rapidly in smokers (both tobacco and marijuana) and higher dosages may be required.
PREGNANCY: There are no adequate studies in pregnant women.
NURSING MOTHERS: Theophylline is excreted in breast milk and may cause mild side effects such as irritability in the infant.
SIDE EFFECTS: Common side effects include nausea, vomiting, diarrhea, headaches, irritability, flushing and palpitations. More serious side effects include seizures and heart arrhythmias. Theophylline should be used cautiously in patients with high blood pressure, peptic ulcer disease, seizure disorders, and serious heart disease, especially heart rhythm problems.
Reference: FDA Prescribing Information
Last Editorial Review: 2/29/2012
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