theophylline, Respbid, Slo-Bid, Theo-24, (Theolair, Uniphyl Theo-Dur, and Slo-Phyllin-discontinued) (cont.)

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Capsule (extended release): 100, 200, 300, and 400 mg

STORAGE: Theophylline should be stored at room temperature, below 77 C F (25 C) in a tightly closed container.

PRESCRIBED FOR: Theophylline is used for the relief and prevention of airway narrowing (bronchospasm) in patients with asthma. Theophylline also can be used in treating patients with emphysema and chronic bronchitis when their symptoms are related to reversible airway narrowing. Theophylline can be administered together with other bronchodilators, such as albuterol (Ventolin, Proventil) for added bronchodilator effect.

DOSING: Theophylline may be taken with or without food but should not be crushed or chewed. High blood theophylline levels can lead to symptoms of toxicity (see below). Therefore, theophylline blood levels are monitored periodically during treatment to assure achievement of optimal and safe levels. The initial dose is 300-600 mg once daily or as a divided dose for 3 days. The maintenance dose is 400-600 mg daily.

DRUG INTERACTIONS: Certain groups of patients breakdown theophylline slowly, and can develop elevated blood levels and potential toxicity even on normal doses. These patients include those with liver disease, older men with chronic lung diseases, infants, patients with high fever or heart failure, and patients taking other medications that increase blood theophylline levels.

Examples of medications that can elevate theophylline blood levels include ephedrine, allopurinol (Zyloprim), cimetidine (Tagamet), ciprofloxacin (Cipro), clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole, erythromycin, oral contraceptives, fluvoxamine (Luvox), and propranolol (Inderal).



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