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February 10, 2012

Tetanus (cont.)

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What are the side effects of tetanus immunization?

Side effects of tetanus immunization occur in approximately 25% of vaccine recipients. The most frequent side effects are usually quite mild (and familiar) and include soreness, swelling, and/or redness at the site of the injection. More significant reactions are extraordinarily rare. The incidence of this particular reaction increases with decreasing interval between boosters.

What is passive immunization (by way of specialized immunoglobulin)?

In individuals who exhibit the early symptoms of tetanus or in those whose immunization status is unknown or significantly out of date, the tetanus immunoglobulin (TIG) is given into the muscle surrounding the wound with the remainder of the dose given into the buttocks.

REFERENCES:

American Academy of Pediatrics. "Tetanus (Lockjaw)." In: Pickering, L.K., ed. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2009.

Braunwald, Eugene, et al. Harrison's Principles of Internal Medicine, 17th ed. United States: McGraw-Hill, 2008.


Last Editorial Review: 9/16/2011


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