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Testosterone Therapy to Treat ED (cont.)

In this Article

  • What causes testosterone deficiency?
  • What are the symptoms of testosterone deficiency?
  • What changes occur in the body due to testosterone deficiency?
  • How do I find out if I have a testosterone deficiency?
  • How is testosterone deficiency treated?
  • Who shouldn't take testosterone replacement therapy?
  • What are the side effects of testosterone replacement therapy?
  • Testosterone Therapy to Treat ED Index

What Are the Symptoms of Testosterone Deficiency?

Without adequate testosterone a man may lose his sex drive, experience erectile dysfunction, feel depressed, have a decreased sense of well-being, and have difficulty concentrating.

What Changes Occur in the Body Due to Testosterone Deficiency?

How Do I Find Out if I Have a Testosterone Deficiency?

The only accurate way to detect the condition is to have your doctor measure the amount of testosterone in your blood. Because testosterone levels fluctuate throughout the day, several measurements will need to be taken to detect a deficiency. Doctors prefer, if possible, to test levels early in the morning since this is when testosterone levels are at their highest.

How Is Testosterone Deficiency Treated?

Testosterone deficiency can be treated by:

  • Intramuscular injections, generally every two or three weeks
  • Testosterone patch worn either on the body or on the scrotum (the sac that contains the testicles)
  • Testosterone gel
  • Mucoadhesive material applied above the teeth twice a day

Each of these options provides adequate levels of hormone replacement; however, they all have different advantages and disadvantages. Talk to your doctor to see which approach may be right for you.

Who Shouldn't Take Testosterone Replacement Therapy?

Men who have prostate cancer or breast cancer should not take testosterone replacement therapy. All men considering testosterone replacement therapy should undergo a thorough prostate cancer screening prior to starting this therapy.

What Are the Side Effects of Testosterone Replacement Therapy?

In general, hormone replacement therapy is safe. It is associated with some side effects, including:

  • Acne or oily skin
  • Mild fluid retention
  • Stimulation of prostate tissue, with perhaps some increased urination symptoms such as a decreased stream or frequency
  • Breast enlargement
  • Worsening of sleep apnea (a sleep disorder that results in frequent night time awakenings and daytime sleepiness)
  • Decreased testicular size

Laboratory abnormalities that can occur with hormone replacement include:

  • Changes in cholesterol concentrations
  • Increase in red blood cell count
  • Decrease in sperm count, producing infertility (especially in younger men)

If you are taking hormone replacement therapy, regular follow-up appointments with your doctor are important.

Like any other medication, directions for administering testosterone should be followed exactly as your doctor orders. If you are unsure or have any questions about testosterone replacement therapy, ask your doctor.

Reviewed by the doctors at the Glickman Urological Institute at The Cleveland Clinic.

Edited by Charlotte E. Grayson, MD, WebMD, June 2004.

Portions of this page © The Cleveland Clinic 2000-2004



Last Editorial Review: 1/31/2005 5:26:13 AM




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  • testosterone gel-topical, Androgel, Testim - Consumer information about the medication TESTOSTERONE GEL - TOPICAL (Androgel, Testim), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug TESTOSTERONE GEL - TOPICAL.
  • Erectile Dysfunction (Impotence) - Read about erectile dysfunction (ED) / impotence includes what it is, how ED is diagnosed, and treatment options.
  • testosterone-transdermal, Androderm, Testoderm TTS - Consumer information about the medication TESTOSTERONE - TRANSDERMAL (Androderm, Testoderm TTS), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug TESTOSTERONE - TRANSDERMAL.

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