GENERIC NAME: teriflunomide
BRAND NAME: Aubagio
DRUG CLASS AND MECHANISM: Teriflunomide is an oral immunomodulatory agent used for the treatment of patients with relapsing forms of multiple sclerosis (MS). It inhibits dihydroorotate dehydrogenase, an enzyme used to make pyrimidine which is used to build DNA. The exact mechanism of action of teriflunomide in the treatment of MS is unknown. However, it is thought to reduce the over activation of the immune system by decreasing the number of white blood cells (T and B lymphocytes) in the central nervous system. Teriflunomide decreases the number of MS relapses. The FDA approved teriflunomide in September 2013.
GENERIC AVAILABLE: No
PREPARATIONS: Film-coated tablets: 7 mg and 14 mg
STORAGE: Tablets should to be stored at 20 C to 25 C (68 F to 77 F), but also may be stored at 15 C to 30 C (59 F to 86 F)
PRESCRIBED FOR: Teriflunomide is used for the treatment of patients with relapsing forms of multiple sclerosis (MS).
DOSING: The recommended dose is one 7 mg or 14 mg tablet once daily with or without food. Note that a monthly blood test for liver enzyme measurements for 6 months is recommended to detect potential liver problems (see side effects section).
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