- What is teriflunomide, and how does it work (mechanism of action)?
- What brand names are available for teriflunomide?
- Is teriflunomide available as a generic drug?
- Do I need a prescription for teriflunomide?
- What are the side effects of teriflunomide?
- What is the dosage for teriflunomide?
- Which drugs or supplements interact with teriflunomide?
- Is teriflunomide safe to take if I'm pregnant or breastfeeding?
- What else should I know about teriflunomide?
What is teriflunomide, and how does it work (mechanism of action)?
Teriflunomide is an oral immunomodulatory agent used for the treatment of patients with relapsing forms of multiple sclerosis (MS). It inhibits dihydroorotate dehydrogenase, an enzyme used to make pyrimidine which is used to build DNA. The exact mechanism of action of teriflunomide in the treatment of MS is unknown. However, it is thought to reduce the over activation of the immune system by decreasing the number of white blood cells (T and B lymphocytes) in the central nervous system. Teriflunomide decreases the number of MS relapses. The FDA approved teriflunomide in September 2013.
What brand names are available for teriflunomide?
Is teriflunomide available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for teriflunomide?
What are the side effects of teriflunomide?
The most common side effects associated with teriflunomide treatment are alopecia (hair thinning or loss), diarrhea, influenza, paresthesia (tingling, burning, prickling or pricking sensations of the skin), and increase in liver enzymes. Serious liver injury, kidney problems, decrease in white blood cell counts, risk for serious infections such as tuberculosis, increase in blood potassium levels (hyperkalemia), increase in blood pressure, breathing problems, and serious skin problems were also reported in clinical studies.
Quick GuideMultiple Sclerosis (MS) Symptoms and Treatment
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