terbutaline, Brethine, Bricanyl, and Brethaire are no longer available in the U.S. (cont.)

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PREPARATIONS: Tablets: 2.5 and 5 mg. Injection: 1 mg/ml. Inhaler: 0.2 mg/puff. Nubulizer: 1 mg/ml.

STORAGE: Tablets and injection should be stored at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Terbutaline is used to relieve and prevent bronchospasms caused by asthma, emphysema or bronchitis. It also is used for preventing preterm labor.

DOSING: The recommended adult oral dose for treating bronchospasm due to asthma, emphysema, or bronchitis is 2.5-5 mg 3 to 4 times daily approximately 6 hours apart while awake. The maximum dosage is 15 mg/day.

The recommended subcutaneous (under skin) dose is 0.25 mg every 15-30 minutes for two doses. The maximum dose is 0.5 mg within 4 hours.

The recommended dose for the inhaler is 2 puffs every 4 to 6 hours.

The dose for preterm labor is 2.5 to 10 mcg/min by intravenous infusion initially, then increase amounts every 10 to 20 minutes. The typical effective dose is 17.5 to 30 mcg/min. Treatment should not exceed 72 hours.

DRUG INTERACTIONS: Combining terbutaline with thioridazine (Mellaril) may increase the occurrence of abnormal heart rhythms because both drugs can cause abnormal heart rhythms. The effects of terbutaline (a beta stimulant) are reversed by beta-blockers, for example, atenolol (Tenormin), nadolol (Corgard), propranolol (Inderal), and metoprolol (Lopressor). Conversely, terbutaline may reduce the effect of beta-blockers. Therefore, terbutaline and beta-blockers should not be used together.

PREGNANCY: Terbutaline reduces uterine contractions and may inhibit labor. There are no adequate studies of terbutaline in pregnant women.

NURSING MOTHERS: Terbutaline is found in small amounts in the breast milk of nursing women. The American Academy of Pediatrics considers terbutaline to be compatible with breastfeeding.

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