terbutaline, Brethine, Bricanyl, and Brethaire are no longer available in the U.S. (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 2.5 and 5 mg. Injection: 1 mg/ml. Inhaler: 0.2 mg/puff. Nubulizer: 1 mg/ml.
STORAGE: Tablets and injection should be stored at room temperature, 15-30 C (59-86 F).
DOSING: The recommended adult oral dose for treating bronchospasm due to asthma, emphysema, or bronchitis is 2.5-5 mg 3 to 4 times daily approximately 6 hours apart while awake. The maximum dosage is 15 mg/day.
The recommended subcutaneous (under skin) dose is 0.25 mg every 15-30 minutes for two doses. The maximum dose is 0.5 mg within 4 hours.
The recommended dose for the inhaler is 2 puffs every 4 to 6 hours.
The dose for preterm labor is 2.5 to 10 mcg/min by intravenous infusion initially, then increase amounts every 10 to 20 minutes. The typical effective dose is 17.5 to 30 mcg/min. Treatment should not exceed 72 hours.
DRUG INTERACTIONS: Combining terbutaline with thioridazine (Mellaril) may increase the occurrence of abnormal heart rhythms because both drugs can cause abnormal heart rhythms. The effects of terbutaline (a beta stimulant) are reversed by beta-blockers, for example, atenolol (Tenormin), nadolol (Corgard), propranolol (Inderal), and metoprolol (Lopressor). Conversely, terbutaline may reduce the effect of beta-blockers. Therefore, terbutaline and beta-blockers should not be used together.
PREGNANCY: Terbutaline reduces uterine contractions and may inhibit labor. There are no adequate studies of terbutaline in pregnant women.
NURSING MOTHERS: Terbutaline is found in small amounts in the breast milk of nursing women. The American Academy of Pediatrics considers terbutaline to be compatible with breastfeeding.
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