telmisartan, Micardis (cont.)

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Medical and Pharmacy Editor:

PRESCRIBED FOR: Telmisartan is used for the treatment of hypertension (high blood pressure). It also is used for reducing the risk of heart attack, stroke, or death from cardiovascular causes in patients 55 years of age or older at high risk of developing major cardiovascular events but who are unable to take ACE inhibitors.

DOSING: The recommended dose for treating hypertension is 20-80 mg daily. The recommended dose for cardiovascular risk reduction is 80 mg daily.

DRUG INTERACTIONS: Telmisartan can increase blood concentrations of digoxin (Lanoxin) and lithium (Eskalith, Lithobid). Therefore blood levels of digoxin and lithium should be monitored and doses adjusted if necessary. Combining telmisartan with potassium-sparing diuretics (for example., spironolactone (Aldactone), triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to hyperkalemia (elevated potassium in the blood). Combining telmisartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. There have been reports that aspirin and other NSAIDs such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ARBs.



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