telaprevir (Incivek) (cont.)

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Medical and Pharmacy Editor:

Telaprevir should be used with caution with arrhythmia medications because the combination can increase the risk of irregular heart rate and rhythm.

Telaprevir (Incivek) should be used with caution with antifungal medications like ketoconazole (Nizoral), itraconazole (Sporanox), and posaconazole (Noxafil); antibiotics erythromycin (Erythrocin) and clarithromycin (Biaxin); immunosuppressant medications like cyclosporine (Gengraf, Neoral, Sandimmune), tacrolimus (Prograf), and sirolimus (Rapamune). Telaprevir can slow the breakdown of these medications and increase their levels in the body, leading to increased side effects and toxicity.

Telaprevir should be used with caution with warfarin (Coumadin) because telaprevir can increase or decrease warfarin (Coumadin) breakdown, increasing or decreasing the effect of warfarin.

PREGNANCY: Telaprevir is combined with ribavirin and peginterferon alfa which cause fetal harm and birth defects if used in pregnant mothers or in male partners of women who are pregnant. Female patients of childbearing potential and their male partners as well as male patients and their female partners must use two effective contraceptive methods during treatment and for 6 months after treatment. Female patients should have monthly pregnancy tests during treatment and for 6 months after stopping treatment.

NURSING MOTHERS: It is not known whether telaprevir enters breast milk; therefore, it is best to be cautious before using it in nursing mothers. To avoid any potential risk to the newborn, a decision must be made to discontinue nursing or to discontinue the drug.

SIDE EFFECTS: Side effects of telaprevir are itching, rash, anal or rectal pain, hemorrhoids, nausea, vomiting, diarrhea, altered taste senses, fatigue, and anemia.

Telaprevir can cause serious skin reactions or rash, including Stevens Johnson syndrome (SJS), drug reaction with eosinophilia and systemic symptoms (DRESS), and toxic epidermal necrolysis (TEN). Telaprevir should be discontinued if serious skin reactions or rash occur.

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 8/27/2014


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