telaprevir (Incivek) (cont.)

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PREPARATIONS: Tablets: 375 mg

STORAGE: Store telaprevir tablets between temperatures of 15 C 30 C (59 F 86 F).

PRESCRIBED FOR: Telaprevir is used for treating chronic hepatitis C genotype 1 infection, in combination with peginterferon alfa (PegIntron) and ribavirin (Rebetol) in adults with compensated liver disease who have not been treated before or failed previous treatment.


Adults (18 years of age and older): The recommended dose of telaprevir (is three 375 mg tablets (1125 mg) by mouth twice daily given 10 to 14 hours apart with food that is not low in fat. Fat increases the absorption of telaprevir.

Telaprevir (Incivek) must be administered with both peginterferon alfa and ribavirin for all patients for 12 weeks, followed by a response-based regimen of either 12 or 36 additional weeks of peginterferon alfa and ribavirin depending on viral response and prior response status.

Safe and effective use of telaprevir (Incivek) in patients under 18 years of age has not been established. 

DRUG INTERACTIONS: Telaprevir should not be combined with alfuzosin (Uroxatral), sildenafil (Viagra), and tadalafil (Cialis) because it can increase their blood levels, leading to increased side effects from these drugs.

Telaprevir (Incivek) is not combined with carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, and St. John's wort because they can increase the breakdown of telaprevir and decrease the effectiveness.

Medically Reviewed by a Doctor on 8/27/2014

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