telaprevir (Incivek) (cont.)

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Medical and Pharmacy Editor:

DOSING:

Adults (18 years of age and older): The recommended dose of telaprevir (is three 375 mg tablets (1125 mg) by mouth twice daily given 10 to 14 hours apart with food that is not low in fat. Fat increases the absorption of telaprevir.

Telaprevir (Incivek) must be administered with both peginterferon alfa and ribavirin for all patients for 12 weeks, followed by a response-based regimen of either 12 or 36 additional weeks of peginterferon alfa and ribavirin depending on viral response and prior response status.

Safe and effective use of telaprevir (Incivek) in patients under 18 years of age has not been established. 

DRUG INTERACTIONS: Telaprevir should not be combined with alfuzosin (Uroxatral), sildenafil (Viagra), and tadalafil (Cialis) because it can increase their blood levels, leading to increased side effects from these drugs.

Telaprevir (Incivek) is not combined with carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, and St. John's wort because they can increase the breakdown of telaprevir and decrease the effectiveness.

Telaprevir should not be combined with lovastatin (Mevacor) and simvastatin (Zocor) due to increased risk of muscle aches, including rhabdomyolysis.

Telaprevir (Incivek) should be combined with midazolam (Versed) and triazolam (Halcion) because of increased risk of sedation and respiratory depression.

Telaprevir (should be used with caution with HIV medications like atazanavir (Reyataz), ritonavir, (Norvir), darunavir (Prezista), fosamprenavir (Lexiva), efavirenz (Sustiva), and lopinavir/ritonavir (Kaletra) because it leads to fluctuating levels of telaprevir and the HIV medications, leading to decreased effectiveness.

Medically Reviewed by a Doctor on 8/27/2014


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