telaprevir (Incivek)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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GENERIC NAME: telaprevir

BRAND NAME: Incivek (This drug was discontinued by the manufacturer, but will be available until October 2014)

DRUG CLASS AND MECHANISM: Telaprevir is a man-made antiviral medication that targets hepatitis C virus (HCV). Similar drugs include simeprevir (Olysio) and boceprevir (Victrelis). These drugs are called direct-acting antiviral agents because they act directly on hepatitis C virus. They block the replication of hepatitis C virus in human cells by binding to and inhibiting protease enzymes that HCV use for reproducing. Inhibiting viral replication reduces HCV viral load in the body to undetectable levels in some patients. The FDA approved Telaprevir in August 2011.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Tablets: 375 mg

STORAGE: Store telaprevir tablets between temperatures of 15 C 30 C (59 F 86 F).

PRESCRIBED FOR: Telaprevir is used for treating chronic hepatitis C genotype 1 infection, in combination with peginterferon alfa (PegIntron) and ribavirin (Rebetol) in adults with compensated liver disease who have not been treated before or failed previous treatment.

DOSING:

Adults (18 years of age and older): The recommended dose of telaprevir (is three 375 mg tablets (1125 mg) by mouth twice daily given 10 to 14 hours apart with food that is not low in fat. Fat increases the absorption of telaprevir.

Medically Reviewed by a Doctor on 8/27/2014

Quick GuideHepatitis C Pictures Slideshow: Transmission, Symptoms and Treatment

Hepatitis C Pictures Slideshow: Transmission, Symptoms and Treatment
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