tamoxifen, Soltamox, Nolvadex (Discontinued) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREPARATIONS: Tablets: 10 and 20 mg. Solution: 10 mg/5 ml

DRUG INTERACTIONS:

  • Tamoxifen increases the blood thinning effect of warfarin (Coumadin) and reduces blood levels of letrozole (Femara) and anastrozole (Arimidex).
  • Phenobarbital and rifampin may reduce blood levels of tamoxifen by increasing the breakdown of tamoxifen.

PREGNANCY AND BREASTFEEDING SAFETY:

  • Tamoxifen should not be used during pregnancy because it can harm the fetus.
  • It is not known whether tamoxifen is excreted in breast milk. Tamoxifen causes a reduction in milk production. Women taking tamoxifen should not breastfeeding.

STORAGE: Tamoxifen should be stored in a dry place at 15 C - 30 C (59 F - 86 F).

DOSING:

  • The dose for metastatic breast cancer treatment, DCIS, and prevention of breast cancer is 10 mg twice daily or 20 mg once daily for 5 years.
  • he dose for stimulation of ovulation is 5-40 mg twice daily for 4 days.
  • Tamoxifen can be taken with food.
Medically Reviewed by a Doctor on 5/24/2016


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