tamoxifen, Nolvadex

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GENERIC NAME: tamoxifen

BRAND NAME: Nolvadex (Discontinued)

DRUG CLASS AND MECHANISM: Tamoxifen is an anti-estrogen that prevents the effects of estrogens on tissues. The precise mechanism of its action is unknown, but one possibility is that it binds and blocks estrogen receptors on the surface of cells, preventing estrogens from binding and activating the cell. It is used in patients for treating and preventing breast cancer. Tamoxifen was approved by the FDA in December 1997.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 10 and 20 mg. Solution: 10 mg/5 ml

STORAGE: Tamoxifen should be stored in a dry place at 15-30 C (59-86 F).

PRESCRIBED FOR: Tamoxifen is used for the treatment of invasive breast cancer in men and women, the most common type of breast cancer, following surgery and/or radiation and for preventing invasive breast cancer in women at high risk for developing it. Tamoxifen also is used for the treatment of women following surgery and radiation for a less common type of breast cancer called ductal carcinoma in situ (DCIS or intraductal carcinoma). Women who have had DCIS are at high risk for developing invasive breast cancer at a later date, and tamoxifen prevents development of the invasive cancer in almost half of the women during the first five years of treatment. Occasionally, tamoxifen is used to stimulate ovulation.




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