MedicineNet.com
  MedicineNet home Health news and views Diseases and conditions Symptoms and signs Procedures and tests Medications Health and Living MedTerms medical dictionary  
Font Size
A
A
A


Medication Written by Pharmacists Reviewed by Doctors

Medical and Pharmacy Editor: Jay Marks, M.D.

GENERIC NAME: tadalafil

BRAND NAME: Cialis

DRUG CLASS AND MECHANISM: Tadalafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection). It is in a class of drugs called phosphodiesterase inhibitors that also includes sildenafil (Viagra) and vardenafil (Levitra).

Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.

Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively, and causing the erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood.

Tadalafil was approved by the FDA in November, 2003.

PRESCRIPTION: Yes.

GENERIC AVAILABLE: No.

PREPARATIONS: Tablets: 5, 10, and 20 mg.

STORAGE: Store at room temperature between 15-30°C (59-86°F).

PRESCRIBED FOR: Tadalafil is used for the treatment of impotence.

DOSING: For most individuals, the recommended starting dose of tadalafil is 10 mg per day taken before sexual activity. Depending on the adequacy of the response or side effects, the dose may be increased to 20 mg or decreased to 5 mg a day. The effect of tadalafil may last up to 36 hours. Individuals who are taking medications that increase the blood levels of tadalafil should not exceed a total dose of 10 mg in 72 hours (See drug interactions). Tadalafil may be taken with or without food since food does not affect its absorption from the intestine.

DRUG INTERACTIONS: The breakdown and elimination of tadalafil from the body may be decreased by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir). Therefore, these drugs may increase the levels of tadalafil in the blood. If these drugs are being used at the same time as tadalafil, the dose of tadalafil should be reduced in order to avoid side effects from high levels of tadalafil.

Tadalafil exaggerates the increases in heart rate and lowering of blood pressure caused by nitrates, e.g. nitroglycerin, isosorbide dinitrate (Isordil), isosorbide mononitrate (Imdur, Ismo, Monoket), nitroglycerin (Nitro-Dur, Transderm-Nitro) that are used primarily for treating heart pain (angina). In patients who take nitrates for angina, tadalafil could cause heart pain or possibly even a heart attack by exaggerating the increase in heart rate and the lowering of blood pressure. Therefore, tadalafil should not be used with nitrates. Tadalafil also exaggerates the blood pressure lowering effects of some alpha-blocking drugs e.g., terazosin (Hytrin) that primarily are used for treating high blood pressure or enlargement of the prostate. Individuals who take these alpha-blockers should be on a stable dose of the alpha-blocker before tadalafil is started. In such situations, tadalafil should be started at the lowest dose. If the patient is already taking tadalafil, the alpha-blocker should be started at the lowest dose. Tadalafil and alcohol both lower blood pressure. Therefore, combining tadalafil with alcohol may cause excessive drops in blood pressure and cause dizziness, headaches and increased heart rate.

PREGNANCY: Tadalafil is not approved for use in women.

NURSING MOTHERS: Tadalafil has not been evaluated in women who are breastfeeding.

SIDE EFFECTS: The most common side effects of tadalafil are facial flushing (reddening), headaches, stomach upset, diarrhea, flu-like symptoms and nausea. Tadalafil also may cause low blood pressure, blurred vision and changes in color vision, and abnormal ejaculation. Tadalafil has been associated with prolonged erections or priapism (painful erections lasting more than 6 hours). Patients should seek immediate medical help if they experience an erection lasting more than 4 hours. Use of tadalafil, most often in patients with pre-existing heart disease, has been associated with chest pain, heart attacks, death, strokes, palpitations and increased heart rate; however, it is not clear whether these side effects are due to tadalafil, concurrent use of nitrates, or the sexual activity itself. Rare cases of sudden loss of hearing have been reported with phosphodiesterase inhibitors such as tadalafil, sometimes associated with ringing in the ears and dizziness.  If changes in hearing occur, patients should stop their tadalafil and seek immediate medical attention. 






Printer-Friendly Format  |  Email to a Friend


space Related health and medical articles From the Doctors at MedicineNet.com MedicineNet Doctors recommend space
space
MedicineNet Doctors Recommend Latest Medical News
space

Back to Medications Index


Last Editorial Review: 10/19/2007





Topics Related to tadalafil, Cialis

tadalafil
RSS FeedSpecialty RSS       Add to My Yahoo! What is this?

Pump Up Your LibidoPump Up Your Libido
We all know that exercise can tone our bodies and make them more attractive. But improve our sex life? Absolutely! See more WebMD Videos »

Erectile Dysfunction

Find tips and advances in treatment.











Health categories:

News & Views | Diseases & Conditions | Symptoms & Signs | Procedures & Tests | Medications | Health & Living | Medical Dictionary

Popular health centers:

Allergies | Arthritis | Cancer | Diabetes | Digestion | Healthy Kids | Heart | Men's Health | Mental Health | Women's Health | More...

Publications:

ePublications (PDFs) | XML News via RSS | Audio Podcasts | Email Newsletters

MedicineNet.com:

About Us | Privacy Policy | Search Help | Site Map | WebMD® | Medscape® | eMedicine® | eMedicineHealth® | RxList®

HON Code We comply with the HONcode standard for health trust worthy information:
verify here.

©1996-2008 MedicineNet, Inc. All rights reserved. Notices and Legal Disclaimer.
MedicineNet does not provide medical advice, diagnosis or treatment. See additional information.