tacrolimus (Prograf, Astagraf XL, Envarsus XR)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

DOSAGE:

  • Oral tacrolimus is taken twice daily.
  • Starting doses range between 0.075 mg/kg/day to 0.2 mg/kg/day (immediate release capsules).
  • Doses vary widely and are based on tests that measure the amount of tacrolimus in the blood.
  • Taking tacrolimus with food can reduce some of the abdominal pain that can occur with this medicine; however, food can reduce the amount of tacrolimus that is absorbed. This is especially true with fatty foods.
  • Capsules should be taken consistently with or without food in order to avoid major swings in blood levels.
  • Grapefruit juice increases blood levels of tacrolimus and should be avoided.
  • The injection is only used for patients who cannot tolerate tacrolimus capsules.

DRUG INTERACTIONS:

Medically Reviewed by a Doctor on 9/29/2016

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