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tacrolimus - injection, Prograf (cont.)

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: cyclosporine, drugs that increase your potassium levels (e.g., potassium-sparing diuretics such as spironolactone, potassium supplements, ACE inhibitors such as lisinopril), drugs that may harm the kidneys (e.g., amphotericin B, cisplatin, ganciclovir, aminoglycosides such as gentamicin), mycophenolate, natalizumab, temsirolimus, sirolimus, ziprasidone.Many drugs besides tacrolimus may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others.Other medications can affect the removal of tacrolimus from your body, which may affect how tacrolimus works. Examples include cimetidine, danazol, bromocriptine, nefazodone, ethinyl estradiol, methylprednisolone, caspofungin, azole antifungals including itraconazole, calcium channel blockers including nifedipine, proton pump inhibitors including omeprazole/lansoprazole, HIV protease inhibitors including nelfinavir/ritonavir, rifamycins including rifampin/rifabutin, certain anti-seizure medicines including carbamazepine/phenytoin/phenobarbital, St. John's wort, among others.



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