tacrine, (Cognex - discontinued in the U.S.)

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USES: Tacrine is used for the treatment of mild to moderate dementia of the Alzheimer's type.

SIDE EFFECTS: The most common side effect of tacrine is an increase in a liver test called alanine aminotransferase (ALT) as a result of liver damage. When a patient starts taking tacrine, blood is drawn on a weekly basis to measure ALT. If there is an increase in blood ALT, the dosage of tacrine can be reduced. Other side effects of tacrine include:

PREPARATIONS: Capsules: 10, 20, 30, and 40 mg.

DRUG INTERACTIONS: Drugs with anticholinergic properties and which cross into the brain, such as atropine, benztropine (Cogentin), and trihexyphenidyl (Artane) produce opposite effects of tacrine and should be avoided during therapy with tacrine. Unlike donezepril (Aricept), tacrine does not reduce the elimination of other drugs, increasing their levels in blood and the likelihood of their side effects.

Medically Reviewed by a Doctor on 1/22/2016

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