tacrine, (Cognex - discontinued in the U.S.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: tacrine
BRAND NAME: Cognex (Discontinued in the USA)
DRUG CLASS AND MECHANISM: Tacrine is an oral medication used to treat patients with Alzheimer's disease. Tacrine is in a class of drugs called cholinesterase inhibitors that also includes rivastigmine (Exelon), donepezil (Aricept), and galantamine (Razadyne - formerly Reminyl). Cholinesterase inhibitors inhibit (block) the action of acetylcholinesterase, the enzyme responsible for the destruction of acetylcholine. Acetylcholine is one of several neurotransmitters in the brain, chemicals that nerve cells use to communicate with one another. Reduced levels of acetylcholine in the brain are believed to be responsible for some of the symptoms of Alzheimer's disease. By blocking the enzyme that destroys acetylcholine, rivastigmine increases the concentration of acetylcholine in the brain, and this increase is believed to be responsible for the improvement in thinking seen with tacrine. Tacrine was approved by the FDA in 1993.
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 10, 20, 30, and 40 mg.
STORAGE: Capsules should be stored at room temperature, 15-30 C (59-86 F).
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