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November 24, 2009
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Sweat Chloride Test (cont.)

Can a cystic fibrosis child have a normal sweat chloride level?

In a severely malnourished patient with cystic fibrosis, the sweat chloride level may be normal. However, once the malnutrition is corrected, the test becomes positive.

Can the sweat chloride be high without having cystic fibrosis?

There are a few rare conditions which produce a false positive sweat chloride test. Such situations include diseases of the adrenal, thyroid, or pituitary glands; rare lipid storage diseases; and infection of the pancreas. Generally, however, these children are easily differentiated from patients with cystic fibrosis by their clinical condition, and molecular tests for cystic fibrosis can be done to clarify the diagnosis.


Last Editorial Review: 1/28/2009




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