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Sweat Chloride Test
(Cystic Fibrosis)

Medical Author: David Perlstein, MD, FAAP
Medical Author: Melissa Conrad Stöppler, MD

What is the sweat chloride test?

The sweat chloride test is a common and simple test used to evaluate a patient who is suspected of having cystic fibrosis (CF), the most common lethal genetic disease affecting Caucasians. Cystic fibrosis is often clinically suspected when there is poor growth during infancy or recurrent serious intestinal or respiratory diseases in a toddler or young child. The genetic defect in cystic fibrosis affects the way chloride moves in and out of cells, and sweat contains chloride in the form of sodium chloride (salt). Measurement of the chloride in sweat has been the standard method for diagnosing cystic fibrosis for over 40 years. Because cystic fibrosis is so common, many states include testing for the cystic fibrosis gene as part of the Newborn Screen; however, sweat testing is still required to confirm the diagnosis.




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Sweat Chloride Test (Cystic Fibrosis)

Genetic Counseling »

What are genetic professionals and what do they do?

Genetics professionals are health care professionals with specialized degrees and experience in medical genetics and counseling. Genetics professionals include geneticists, genetic counselors and genetics nurses.

What is genetic counseling and evaluation?

Genetic professionals work as members of health care teams providing information and support to individuals or families who have genetic disorders or may be at risk for inherited conditions. Genetic professionals:

  • Assess the risk of a genetic disorder by researching a family's history and evaluating medical records.
  • Weigh the medical, social and ethical decisions surrounding genetic testing.
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