Dr. Ben Wedro practices emergency medicine at Gundersen Clinic, a regional trauma center in La Crosse, Wisconsin. His background includes undergraduate and medical studies at the University of Alberta, a Family Practice internship at Queen's University in Kingston, Ontario and residency training in Emergency Medicine at the University of Oklahoma Health Sciences Center.
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
The superior vena cava is a large vein located in the upper chest, which
collects blood from the head and arms and delivers it back to the right atrium
of the heart. If this vein is compressed by outside structures, or if a thrombus
or clot develops within it, then return blood flow to the heart is impeded. When
blood flow to the heart is restricted, the increased pressure in the veins of
the face and arms causes edema (fluid buildup) in these areas. This condition is
referred to as superior vena cava syndrome.
Because the superior vena cava, like all veins, has a thin wall (there are no
muscles in the walls of a vein as compared to the walls of an artery), and
because there is little pressure inside the vein, it can be easily compressed by
outside structures. The superior vena cava lies next to the upper lobe of the
right lung and within the mediastinum [the space that contains the central
structures of the chest: the heart, the trachea, the esophagus and the great
vessels (aorta, vena cava)]. Abnormalities within any of these structures can
cause the compression.
What causes superior vena cava syndrome?
The most common cause of superior vena cava syndrome is cancer. Primary
or metastatic cancer in the upper lobe of the right lung can compress
the superior vena cava.
Lymphoma or other tumors located in the mediastinum can also cause compression
of the superior vena cava.
Less often, the superior vena cava can become blocked with a blood clot from
within. As more invasive medical procedures are being performed on patients, this
cause of superior vena cava syndrome is being seen more frequently. Blood clot
(thrombus) formation that causes superior vena cava syndrome is a
complication of pacemaker wires,
dialysis, and other intravenous
catheters that are threaded into the superior vena cava.
Historically, and in other parts of the world, infection (syphilis and
tuberculosis) is another cause of superior vena cava syndrome. Sarcoidosis (a
disease that results in masses of inflamed tissue) may also cause this syndrome.
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis bacteria. Symptoms include weakness, fever, weight loss, night sweats and in worse cases, chest pain, shortness of breath, and coughing up blood. A person with an active infection (a positive TB skin test, abnormal chest x-ray and TB bacteria in their sputum) requires treatment with izoniazid, rifampin, ethambutol and pyrazinaide.
Edema is the swelling of tissues as a result of excess water accumulations. Peripheral edema occurs in the feet and legs. There are two types of edema, non-pitting edema and pitting edema. Causes of pitting edema is caused by systemic diseases, most commonly involving the heart, liver, and kidneys. Local conditions that cause edema are thrombophlebitis and varicose veins. Edema is generally treated with medication.
Sexually transmitted diseases, or STDs,
are infections that are transmitted during any type of sexual exposure,
including intercourse (vaginal or anal), oral sex, and the sharing of sexual
devices, such as vibrators. Women can contract all of the STDs, but may have no symptoms, or have different symptoms than men do.
Sarcoidosis, a disease resulting from chronic inflammation, causes small lumps (granulomas) to develop in a great range of body tissues and can appear in almost any body organ. However, sarcoidosis most often starts in the lungs or lymph nodes.
Chest pain is a common complaint by a patient in the ER. Causes of chest pain include broken or bruised ribs, pleurisy, pneumothorax, shingles, pneumonia, pulmonary embolism, angina, heart attack, costochondritis, pericarditis, aorta or aortic dissection, and reflux esophagitis. Diagnosis and treatment of chest pain depends upon the cause and clinical presentation of the patient's chest pain.
Sexually transmitted diseases, or STDs, are infections that are transmitted during any
type of sexual exposure, including intercourse (vaginal or anal), oral sex, and
the sharing of sexual devices, such as vibrators. Although treatment exists for many STDs, others currently are
usually incurable, such as those caused by HIV, HPV, hepatitis B and C, and HHV-8.
Hoarseness (abnormal deep, harsh, raspy voice) is caused by a variety of conditions in which the larynx (voice box and vocal chords) are irritated or injured. Examples of causes of hoarseness include: laryngitis, straining the vocal cords by yelling or screaming, infections, GERD, allergies, and more. Treatment of hoarseness depends on the cause.
Syphilis, a sexually transmitted disease, is caused by a microscopic, wormlike bacterial organism called a spirochete. There are three stages of syphilis. The first involves the formation of the chancre. The second stage often includes hair loss, a sore throat, white patches in the nose, mouth, and vagina, fever, headaches, and a skin rash. The third stage can cause extensive damage to the internal organs and the brain, and can lead to death. Though early infection often resolves on its own, treatment usually varies based on the stage of the infection at the time of diagnosis.
Chemotherapy (also called chemo) is a type of cancer treatment that uses drugs to destroy cancer cells.
How does chemotherapy work?
Chemotherapy works by stopping or slowing the growth of cancer cells, which grow and divide quickly. But it can also harm healthy cells that divide quickly, such as those that line your mouth and intestines or cause your hair to grow. Damage to healthy cells may cause side effects. Often, side effects get better or go away after chemotherapy is over.
What does chemotherapy do?
Depending on your type of cancer and how advanced it is, chemotherapy can:
Cure cancer - when chemotherapy destroys cancer cells to the point that your doctor can no longer detect them in your body and they will not grow back.
Control cancer - when chemotherapy keeps cancer from spreading, slows its growth, or destroys cancer cell...