GENERIC AVAILABLE: Yes
- Tablets: 25, 50, 100 mg
- Intranasal Solution: 5, 20 mg
- Injection Solution: 4 and 6 mg/0.5 ml
- Transdermal System (Patch): 86 mg (6.5 mg over 4 hours)
- Sumatriptan tablets and solution should be stored between 2 C and 30 C (36 F and 86 F).
- The patch should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
- The recommended oral dose is 25-100 mg and the maximum dose is 200 mg daily.
- The recommended intranasal dose is 5-20 mg and the maximum dose is 40 mg daily.
- The recommended injection dose is 4 or 6 mg injected under the skin. T
- he maximum dose is two 6 mg injections separated by 1 hour.
- The recommended dose for the Zecuity patch is one patch applied to dry intact, non-irritated skin on the upper arm or thigh on a site that is relatively hair free and is without scars, tattoos, abrasions, or other skin conditions.
DRUG INTERACTIONS: Monoamine oxidase inhibitors or MAOIs, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), may reduce the breakdown of sumatriptan in the liver, leading to increased blood levels and side effects of sumatriptan.
Combining sumatriptan with sibutramine (Meridia), selective serotonin reuptake inhibitors or SSRIs, including fluoxetine (Prozac), citalopram (Celexa), paroxetine (Paxil), and sertraline (Zoloft) or serotonin and norepinephrine reuptake inhibitors, including venlafaxine (Effexor), duloxetine (Cymbalta), and desvenlafaxine (Pristiq) may increase the concentration of serotonin in the brain, causing increased serotonin-related side effects.
Administering sumatriptan within 24 hours of treatment with an ergot-containing medication (dihydroergotamine [Migranal], ergotamine [Methergine]) is contraindicated because such combinations increase the likelihood of vasospasms.
PREGNANCY: Safe use in pregnancy has not been established.
NURSING MOTHERS: Sumatriptan is excreted in breast milk. Infant exposure may be reduced by avoiding breast feeding for 12 hours after administration of sumatriptan.
Reference: FDA Prescribing Information
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