DRUG INTERACTIONS: Sulindac may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the elimination of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
Sulindac may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins have a role in the regulation (reduction) of blood pressure. Combining NSAIDs such as sulindac with angiotensin receptor blockers (for example, valsartan [Diovan], losartan [Cozaar], irbesartan [Avapro]) or angiotensin converting enzyme (ACE) inhibitors (for example, enalapril [Vasotec], captopril [Capoten]) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
When sulindac is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycosides from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid sulindac because sulindac also thins the blood, and excessive blood thinning may lead to bleeding.
Persons who consume more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking sulindac or other NSAIDs.
PREGNANCY: There are no adequate studies of sulindac in pregnant women. Therefore, sulindac is not recommended during pregnancy.
NURSING MOTHERS: It is not known whether sulindac is excreted in breast milk.
Reference: FDA Prescribing Information
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