SIDE EFFECTS: Most patients benefit from sulindac and other NSAIDs with few side effects. However, serious side effects can occur and generally tend to be dose related, that is, they occur more frequently with higher doses. Therefore, it is advisable to use the lowest effective dose to minimize side effects.
The most common side effects of sulindac involve the gastrointestinal system, and these are:
- ulcerations of the stomach and small intestine,
- abdominal pain,
- serious gastrointestinal bleeding, and
- liver toxicity.
Sometimes, ulceration of the stomach and bleeding can occur without any abdominal pain, and black tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) may be the only signs of internal bleeding.
Other important side effects include:
Sulindac should be avoided by patients with a history of exacerbation of asthma, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Fluid retention, blood clots, heart attacks, hypertension, and heart failure have also been associated with the use of NSAIDs such as sulindac.
GENERIC AVAILABLE: Yes
PREPARATIONS: tablets: 150 and 200 mg
STORAGE: Sulndac should be stored in a sealed container and protected from moisture at room temperature, 15-30 C (59-86 F).
DOSING: The usual adult dose is 150 or 200 mg given twice daily with meals. The maximum dose is 400 mg daily.
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