The following are health and medical definitions of terms that appear in the sulindac, Clinoril article.
Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs. See the entire definition of Abdominal
Abdominal pain: Pain in the belly (the abdomen). Abdominal pain can come from conditions affecting a variety of organs. The abdomen is an anatomical area that is bounded by the lower margin of the ribs above, the pelvic bone (pubic ramus) below, and the flanks on each side. Although abdominal pain can arise from the tissues of the abdominal wall that surround the abdominal cavity (the skin and abdominal wall muscles), the term abdominal pain generally is used to describe pain originating from organs within the abdominal cavity (from beneath the skin and muscles). These organs include the stomach, small intestine, colon, liver, gallbladder, and pancreas. See the entire definition of Abdominal pain
Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care. See the entire definition of Acute
Angiotensin: A family of peptides (smaller than proteins) that act as vasoconstrictors to narrow blood vessels.
Angiotensin converting enzyme: Usually abbreviated ACE.
Ankylosing: Undergoing ankylosis (stiffening or fusion of a joint).
Ankylosing spondylitis: A type of arthritis that causes chronic inflammation of the spine and the sacroiliac joints. Chronic inflammation in these areas causes pain and stiffness in and around the spine. Over time, chronic spinal inflammation (spondylitis) can lead to a complete cementing together (fusion) of the vertebrae, a process called ankylosis. Ankylosis causes total loss of mobility of the spine. See the entire definition of Ankylosing spondylitis
Aspirin: A good example of a tradename that entered into the language, Aspirin was once the Bayer trademark for acetylsalicylic acid. See the entire definition of Aspirin
Asthma: A common disorder in which chronic inflammation of the bronchial tubes (bronchi) makes them swell, narrowing the airways. Asthma involves only the bronchial tubes and does not affect the air sacs (alveoli) or the lung tissue (the parenchyma of the lung) itself. See the entire definition of Asthma
Blood clots: Blood that has been converted from a liquid to a solid state. Also called a thrombus. See the entire definition of Blood clots
Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".
Breast milk: Milk from the breast. Human milk contains a balance of nutrients that closely matches infant requirements for brain development, growth and a healthy immune system. Human milk also contains immunologic agents and other compounds that act against viruses, bacteria, and parasites. Since an infant's immune system is not fully developed until age 2, human milk provides a distinct advantage over formula. See the entire definition of Breast milk
Bursitis: Bursitis is inflammation of a bursa. A bursa is a tiny fluid-filled sac that functions as a gliding surface to reduce friction between tissues of the body. The major bursae are located adjacent to the tendons near the large joints, such as the shoulders, elbows, hips, and knees.
Diuretic: Anything that promotes the formation of urine by the kidney. (The word "diuretic" comes from a combination of the Greek "dia-", thoroughly + "ourein", to urinate = to urinate thoroughly). See the entire definition of Diuretic
Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo. See the entire definition of Dizziness
Effective dose: The dose of a drug that will achieve the desired effect.
Enzyme: A protein (or protein-based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions, converting a specific set of reactants (called substrates) into specific products. Without enzymes, life as we know it would not exist. See the entire definition of Enzyme
Exacerbation: A worsening. In medicine, exacerbation may refer to an increase in the severity of a disease or its signs and symptoms. For example, exacerbation of asthma is one of the serious effects of air pollution..
FDA: The Food and Drug Administration, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services. See the entire definition of FDA
Fever: Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.). See the entire definition of Fever
Gastritis: Inflammation of the stomach. From the Latin gastricus meaning stomach + -itis, meaning inflammation.
Gastrointestinal: Adjective referring collectively to the stomach and small and large intestines. See the entire definition of Gastrointestinal
Generic:1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.
Gouty arthritis: An attack that is usually extremely painful of joint inflammation due to deposits of uric acid crystals in the joint fluid (synovial fluid) and joint lining (synovial lining). Intense joint inflammation occurs as white blood cells engulf the uric acid crystals, causing pain, heat, and redness of the joint tissues. The term "gout" commonly is used to refer to these painful arthritis attacks but gouty arthritis is only one manifestation of gout.
Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest. See the entire definition of Heart
Heart failure: Inability of the heart to keep up with the demands on it and, specifically, failure of the heart to pump blood with normal efficiency. When this occurs, the heart is unable to provide adequate blood flow to other organs such as the brain, liver and kidneys. Heart failure may be due to failure of the right or left or both ventricles. The signs and symptoms depend upon which side of the heart is failing. They can include shortness of breath (dyspnea), asthma due to the heart (cardiac asthma), pooling of blood (stasis) in the general body (systemic) circulation or in the liver's (portal) circulation, swelling (edema), blueness or duskiness (cyanosis), and enlargement (hypertrophy) of the heart. See the entire definition of Heart failure
Hives: A raised, itchy area of skin that is usually a sign of an allergic reaction. It can be rounded or flat-topped but is always elevated above the surrounding skin. It reflects circumscribed dermal edema (local swelling of the skin). The hives are usually well circumscribed but may be coalescent and will blanch with pressure. They typically last less than 4 hours but they may stay for days or weeks. Approximately 20% of the population has experienced a bout of hives. See the entire definition of Hives
Hypertension: High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. See the entire definition of Hypertension
Hypotension: Any blood pressure that is below the normal expected for an individual in a given environment. Hypotension is the opposite of hypertension (abnormally high blood pressure). See the entire definition of Hypotension
Ibuprofen: A non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, swelling, and fever. Common brand names for Ibuprofen include Advil, Motrin, and Nuprin.
Inflammation: A basic way in which the body reacts to infection, irritation or other injury, the key feature being redness, warmth, swelling and pain. Inflammation is now recognized as a type of nonspecific immune response. See the entire definition of Inflammation
Internal bleeding: Bleeding inside the body that is not seen from the outside. Internal bleeding occurs when damage to an artery or vein allows blood to escape the circulatory system and collect inside the body. The internal bleeding may occur within tissues, organs, or in cavities of the body including the head, chest, and abdomen. Examples of other potential sites of bleeding include the eye, lining tissues of the heart, muscles, and joints. Internal bleeding may not be evident for many hours after it begins, and symptoms occur when there is significant blood loss or if a blood clot is large enough to compress an organ and prevent it from functioning properly.
Intestine: The long, tubelike organ in the abdomen that completes the process of digestion. It consists of the small and large intestines.
Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.
Lightheadedness: A feeling you are "going to faint." Lightheadedness is medically distinct from dizziness, unsteadiness, and vertigo. See: Dizziness, Unsteadiness, and Vertigo.
Lithium: Lithium carbonate (brand names: Eskalith; Lithobid), a drug used as a mood stabilizer for the treatment of manic/depressive (bipolar) disorder. It prevents or diminishes the intensity of episodes of mania in bipolar patients. Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgment, aggressiveness and possibly hostility. See the entire definition of Lithium
Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.
Methotrexate: A drug that acts as an antimetabolite and specifically as a folic acid antagonist that inhibits the synthesis of DNA, RNA, and protein. See the entire definition of Methotrexate
Nausea:Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleeding, a physician should be consulted.
NSAID: Nonsteroidal anti-inflammatory drug. NSAIDs are commonly prescribed for the inflammation of arthritis and other body tissues, such as in tendinitis and bursitis. Examples of NSAIDs include aspirin, indomethacin (Indocin), ibuprofen (Motrin), naproxen (Naprosyn), piroxicam (Feldene), and nabumetone (Relafen). See the entire definition of NSAID
Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.
Orthostatic hypotension: A temporary lowering of blood pressure (hypotension) due usually to suddenly standing up (orthostatic). Orthostatic hypotension may be experienced by healthy people -- it is more common in older people -- who rise quickly from a chair, especially after a meal, and have a few seconds of disorientation. See the entire definition of Orthostatic hypotension
Osteoarthritis: A type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis.
Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors. See the entire definition of Pain
Peptic ulcer: A hole in the lining of the stomach, duodenum, or esophagus. A peptic ulcer of the stomach is called a gastric ulcer, an ulcer of the duodenum is a duodenal ulcer, and a peptic ulcer of the esophagus is an esophageal ulcer. A peptic ulcer occurs when the lining of these organs is corroded by the acidic digestive juices which are secreted by the stomach cells. See the entire definition of Peptic ulcer
Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long. See the entire definition of Pregnancy
Pregnant: The state of carrying a developing fetus within the body. See the entire definition of Pregnant
Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.
Rash: Breaking out (eruption) of the skin. Medically, a rash is referred to as an exanthem.
Receptor:1. In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are many receptors. There is a receptor for (insulin; there is a receptor for low-density lipoproteins (LDL); etc. To take an example, the receptor for substance P, a molecule that acts as a messenger for the sensation of pain, is a unique harbor on the cell surface where substance P docks. Without this receptor, substance P cannot dock and cannot deliver its message of pain. Variant forms of nuclear hormone receptors mediate processes such as cholesterolmetabolism and fatty acid production. Some hormone receptors are implicated in diseases such as diabetes and certain types of cancer. A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions. 2. In neurology, a terminal of a sensorynerve that receives and responds to stimuli.
Rheumatoid arthritis: An autoimmune disease which causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Autoimmune diseases occur when the body tissues are mistakenly attacked by its own immune system. The immune system is a complex organization of cells and antibodies designed normally to "seek and destroy" invaders of the body, particularly infections. Patients with these diseases have antibodies in their blood which target their own body tissues, where they can be associated with inflammation. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. While rheumatoid arthritis is a chronic illness (meaning it can last for years) patients may experience long periods without symptoms. See the entire definition of Rheumatoid arthritis
Ringing in the ears: Medically called tinnitus, this can arise in any of "the four sections of the ear" -- the outer ear, the middle ear, the inner ear, and the brain -- and can be due to many causes including ear infections, fluid in the ears, Meniere syndrome (the combination of tinnitus and deafness), some medications such as aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs), aging, and ear trauma (such as from the noise of planes, firearms, or loud music). In rare situations, tinnitus may also be due to an aneurysm or an acoustic neuroma (a benign tumor on the acoustic nerve). Woodwind players are more likely to experience tinnitus than other orchestral players, probably because they usually sit just in front of the brass. If tinnitus persists or its cause is unknown, a hearing test (audiogram) should be done. Measures can be taken to lessen the intensity of tinnitus or to mask it.
Shoulder: A structure made up of two main bones: the scapula (shoulder blade) and the humerus (the long bone of the upper arm). The end of the scapula, called the glenoid, is a socket into which the head of the humerus fits, forming a flexible ball-and-socket joint. The scapula is an unusually shaped bone. It extends up and around the shoulder joint at the rear to create a roof called the acromion and around the shoulder joint at the front to constitute the coracoid process. The shoulder joint is cushioned by cartilage that covers the face of the glenoid socket and the head of the humerus. The joint is stabilized by a ring of fibrous cartilage around the glenoid socket that is called the labrum. Ligaments connect the bones of the shoulder and tendons join these bones to surrounding muscles. The bicepstendon attaches the biceps muscle to the shoulder and helps stabilize the joint. Four short muscles that originate on the scapula pass around the shoulder where their tendons fuse together to form the rotator cuff.
Small intestine: The part of the digestive tract that extends from the stomach to the large intestine.
Spondylitis: Inflammation of one or more of the vertebrae of the spine. Diffuse inflammation of the spine is seen in the disease ankylosing spondylitis. Localized spondylitis is seen with infections of a certain area of the spine, such as in Pott's disease.
Stomach:1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine. See the entire definition of Stomach
Tendinitis: Inflammation of a tendon (the tissue by which muscle attaches to bone). Tendinitis most commonly occurs as a result of injury, such as to the tendons around the shoulder or elbow. It can also occur as a result of an underlying inflammatory rheumatic disease, such as reactive arthritis or gout. Tendinitis is synonymous with tendonitis.
Toxicity: The degree to which a substance can harm humans or animals. See the entire definition of Toxicity
Ulcer: An area of tissue erosion, for example, of the skin or lining of the gastrointestinal (GI) tract. Due to the erosion, an ulcer is concave. It is always depressed below the level of the surrounding tissue. See the entire definition of Ulcer
Ulceration: The process or fact of being eroded away, as by an ulcer.
Warfarin: An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks. See the entire definition of Warfarin
Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease.
Gout is a condition that results from crystals of uric acid depositing in tissues of the body. Gout is a condition that can lead to abnormally elevated levels of uric acid in the
blood, recurring attacks of joint inflammation (arthritis), deposits of
hard lumps of uric acid in and around the joints, and decreased kidney
function and kidney stones.
Bursitis of the hip results when the fluid-filled sac (bursa) near the hip becomes inflamed due to localized soft tissue trauma or strain. Symptoms include stiffness and pain around the hip joint. If the hip bursa is not infected, hip bursitis can be treated with ice compresses, rest, and antiinflammatory and pain medications.
Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous
system. When only the skin is involved, the condition is called discoid lupus.
When internal organs are involved, the condition is called systemic lupus
erythematosus (SLE).
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammation.
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of
cartilage in the joints. Also known as degenerative arthritis. Osteoarthritis
can be caused by aging, heredity, and injury from trauma or disease.
Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. The tendency to develop ankylosing spondylitis is genetically inherited.
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves antiinflammatory medications and exercise.
Shoulder bursitis is inflammation of the shoulder bursa. Bursitis may be caused by injury, infection, or a rheumatic condition. Symptoms include pain, swelling, tenderness, and pain with movement of the shoulder joint. Treatment may involve ice compresses, rest, and antiinflammatory medications and depends on whether there is an infection.
Bursitis of the knee results when any of the three fluid-filled sacs (bursae) become inflamed due to injury or strain. Symptoms include pain, swelling, warmth, tenderness, and redness. Treatment of knee bursitis depends on whether infection is involved. If the knee bursa is not infected, knee bursitis may be treated with ice compresses, rest, and antiinflammatory and pain medications.
Reactive arthritis is a chronic, systemic rheumatic disease characterized by three conditions, including conjunctivitis, joint inflammation, and genital, urinary or gastrointestinal system inflammation. Inflammation leads to pain, swelling, warmth, redness, and stiffness of the affected joints. Non-joint areas may experience irritation and pain. Treatment for reactive arthritis depends on which area of the body is affected. Joint inflammation is treated with antiinflammatory medications.
Nonsteroidal antiinflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of NSAIDs include aspirin, ibuprofen, naproxen, and more. One common side effect of NSAIDs is peptic ulcer (ulcers of the esophagus, stomach, or duodenum). Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking NSAIDs.
A bursa is a closed
fluid-filled sac that functions as a gliding surface to reduce friction between
tissues of the body. Bursae is plural for bursa. The major bursae are located adjacent to
the tendons near the large joints, such as the shoulders, elbows, hips, and
knees. When a bursa becomes inflamed, the condition is known as bursitis.
Most commonly, bursitis is caused by local soft tissue trauma or strain injury, and there is no
infection (aseptic bursitis). On rare
occasions, the bursa can become infected with bacteria. This condition
is called septic bursitis.
What is knee bursitis?
The knee joint is surrounded by three
major bursae. At the tip of the knee, over the kneecap bone, is
the prepatellar bursa. This bursa can become inflamed (prepatellar
bursitis) from direct trauma to the front of the knee. This commonly
occurs when maintaining a prolonged kneeling position....
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