- Rheumatoid Arthritis Slideshow Pictures
- Take the RA Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is sulindac, and how does it work (mechanism of action)?
- What brand names are available for sulindac?
- Is sulindac available as a generic drug?
- Do I need a prescription for sulindac?
- What are the side effects of sulindac?
- What is the dosage for sulindac?
- Which drugs or supplements interact with sulindac?
- Is sulindac safe to take if I'm pregnant or breastfeeding?
- What else should I know about sulindac?
What is sulindac, and how does it work (mechanism of action)?
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) that is used for treating pain, fever, and inflammation. Other NSAIDs include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) as well as others. They work by reducing the levels of prostaglandins, chemicals that are produced by the body and are responsible for pain, fever, and inflammation. Sulindac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Sulindac was approved by the FDA in September 1978.
What brand names are available for sulindac?
Is sulindac available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for sulindac?
What are the side effects of sulindac?
Most patients benefit from sulindac and other NSAIDs with few side effects. However, serious side effects can occur and generally tend to be dose related, that is, they occur more frequently with higher doses. Therefore, it is advisable to use the lowest effective dose to minimize side effects.
The most common side effects of sulindac involve the gastrointestinal system, and these are:
- ulcerations of the stomach and small intestine,
- abdominal pain,
- serious gastrointestinal bleeding, and
- liver toxicity.
Sometimes, ulceration of the stomach and bleeding can occur without any abdominal pain, and black tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) may be the only signs of internal bleeding.
Other important side effects include:
Sulindac should be avoided by patients with a history of exacerbation of asthma, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Fluid retention, blood clots, heart attacks, hypertension, and heart failure have also been associated with the use of NSAIDs such as sulindac.
Quick GuideRheumatoid Arthritis (RA) Symptoms & Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.