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Serious rashes include:
- Stevens-Johnson syndrome, which includes symptoms like:
- aching joints,
- aching muscles,
- blistering, and
- peeling of the skin
- Toxic epidermal necrolysis, which includes symptoms like:
- difficulty in swallowing,
- loosening, and
- blistering of the skin.
Sulfonamides also may cause sensitivity to the sun that leads to extensive sunburn after exposure to sunlight (photosensitivity). Patients receiving sulfonamides should avoid excessive exposure to sunlight and should wear sunscreen.
Other rare side effects include liver damage, low white blood cell count (leucopenia), low platelet count (thrombocytopenia), and anemia. Formation of urinary crystals which may damage the kidney and may cause blood. Adequate hydration is needed to prevent the formation of urinary crystals.
What are examples of sulfonamides available in the US?
Examples of sulfonamides include:
- sulfamethoxazole/trimethoprim (Bactrim, Bactrim DS, Septra, Septra DS)
- sulfasalazine (Azulfidine, Sulfazine)
- sulfisoxazole (Truxazole)
Many of these drugs are available only in generic forms.
What drugs interact with sulfonamides?
Sulfonamides can increase the blood-thinning effects of warfarin (Coumadin), possibly leading to abnormal bleeding.
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