Sulfonamides (Bactrim, Bactrim DS, Septra, Septra DS)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Bacterial Infections 101 Pictures Slideshow

Serious rashes include:

  • Stevens-Johnson syndrome, which includes symptoms like:
    • aching joints,
    • aching muscles,
    • redness,
    • blistering, and
    • peeling of the skin
  • Toxic epidermal necrolysis, which includes symptoms like:
    • difficulty in swallowing,
    • peeling,
    • redness,
    • loosening, and
    • blistering of the skin.

Sulfonamides also may cause sensitivity to the sun that leads to extensive sunburn after exposure to sunlight (photosensitivity). Patients receiving sulfonamides should avoid excessive exposure to sunlight and should wear sunscreen.

Other rare side effects include liver damage, low white blood cell count (leucopenia), low platelet count (thrombocytopenia), and anemia. Formation of urinary crystals which may damage the kidney and may cause blood. Adequate hydration is needed to prevent the formation of urinary crystals.

What are examples of sulfonamides available in the US?

Examples of sulfonamides include:

Many of these drugs are available only in generic forms.

What drugs interact with sulfonamides?



Sulfonamides can increase the blood-thinning effects of warfarin (Coumadin), possibly leading to abnormal bleeding.

Medically Reviewed by a Doctor on 3/27/2015

Quick GuideInfectious Mononucleosis (Mono): Symptoms and Treatment

Infectious Mononucleosis (Mono): Symptoms and Treatment
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Newsletters

Get the latest health and medical information delivered direct to your inbox!

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors