sulfinpyrazone (Anturane - discontinued in the US) (cont.)

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DOSING: Sulfinpyrazone should be taken with food, milk or antacids. Patients taking sulfinpyrazone long-term should drink plenty of fluids to minimize the risk of uric acid stones forming in the kidneys.

DRUG INTERACTIONS: Sulfinpyrazone can aggravate peptic ulcer disease and is avoided in patients with this condition. It also is avoided in patients with a history of sensitivity to phenylbutazone (Butazolidin) or with serious blood disorders. In patients having an acute attack of gouty arthritis, sulfinpyrazone can worsen the attack. Therefore, it is not started until after the attack has subsided. To avoid a recurrence of gout, while sulfinpyrazone is initiated, colchicine (Colcrys) often is added. Aspirin products can interfere with sulfinpyrazone's effects. Sulfinpyrazone can enhance the action of certain diabetes medicines, such as chlorpropamide (Diabinese), resulting in abnormally low blood sugars.

PREGNANCY: Sulfinpyrazone is avoided, when possible, during pregnancy.

SIDE EFFECTS: Side effects of sulfinpyrazone are uncommon and usually mild. The most frequent adverse reaction is stomach upset. Accordingly, combining the drug with food, milk or antacids is advised. Sulfinpyrazone, however, can cause kidney pain and uric acid kidney stones. Rarely, it has caused severe anemias.

Reference: FDA Prescribing Information

Last Editorial Review: 11/15/2012

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