GENERIC NAMES: Sulfamethoxazole and trimethoprim; cotrimoxazole
BRAND NAMES: Bactrim, Bactrim DS, Sulfatrim Pediatric
DISCONTINUED BRAND: Septra, Septra DS
GENERIC AVAILABLE: Yes
USES: Sulfamethoxazole/trimethoprim is used for treating infections due to susceptible bacteria. Examples include urinary tract infections, flares of chromic bronchitis due to bacteria, middle ear infections, for prevention of infections due to pneumococcus in organ transplant recipients, for the treatment or prevention of Pneumocystis carinii pneumonia, chancroid, and prevention of toxoplasma encephalitis in patients with AIDS.
SIDE EFFECTS:Common side effects of sulfamethoxazole/trimethoprim are:
Other side effects include:
MORE SERIOUS SIDE EFFECTS: Sulfamethoxazole/trimethoprim should be stopped at the first appearance of a skin rash before the rash becomes severe. Serious rashes include Stevens-Johnson syndrome (aching joints and muscles; redness, blistering, and peeling of the skin); toxic epidermal necrolysis (difficulty in swallowing; peeling, redness, loosening, and blistering of the skin).
Sulfamethoxazole/trimethoprim therapy also can cause extensive sunburn, following exposure to sunlight. Patients receiving Sulfamethoxazole/trimethoprim should avoid excessive exposure to sunlight (photosensitivity to drugs) and should wear sunscreen.
Sulfamethoxazole/trimethoprim may form crystals in the urine which may damage the kidney and cause bleeding into the urine. It is important to drink additional liquids during therapy to prevent these side effects.
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