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- What is sulfamethoxazole, and how does it work (mechanism of action)?
- Is sulfamethoxazole available as a generic drug?
- Do I need a prescription for sulfamethoxazole?
- What are the side effects of sulfamethoxazole?
- What is the dosage for sulfamethoxazole?
- Which drugs or supplements interact with sulfamethoxazole?
- Is sulfamethoxazole safe to take if I'm pregnant or breastfeeding?
- What else should I know about sulfamethoxazole?
What is sulfamethoxazole, and how does it work (mechanism of action)?
Sulfamethoxazole is an anti- bacterial sulfonamide. It prevents the formation of dihydrofolic acid, a compound that bacteria must be able to make in order to survive. Although it was once a very useful antibiotic, it is almost obsolete as a single agent today due to the development of bacterial resistance to its effects. Sulfamethoxazole is now used primarily in combination with trimethoprim, a combination product known as Bactrim or Septra. Sulfamethoxazole was approved by the FDA in 1961. According to the FDA database, all brand and generic formulations of sulfamethoxazole have been discontinued.
Is sulfamethoxazole available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for sulfamethoxazole?
What are the side effects of sulfamethoxazole?
: Common side effects of sulfamethoxazole are:
Sulfamethoxazole should be stopped at the first appearance of a skin rash since the rash may become severe. Serious rashes include Stevens-Johnson syndrome (aching joints and muscles; redness, blistering, and peeling of the skin); toxic epidermal necrolysis (difficulty in swallowing; peeling, redness, loosening, and blistering of the skin). Sulfamethoxazole therapy also can cause extensive sunburn, following exposure to sunlight. Patients receiving sulfamethoxazole should avoid excessive exposure to sunlight and should wear sunscreen.
Other important rare side effects include:
Sulfamethoxazole may form crystals in the urine which may damage the kidney and cause bleeding into the urine. It is important to drink additional liquids during sulfonamide therapy to prevent these side effects.
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