sucralfate, Carafate (cont.)

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DOSING: The recommended dose for treatment of active ulcers is 1 gram four times daily for 4-8 weeks. Sucralfate is administered on an empty stomach, at least one hour prior to meals, for best results. The dose for preventing recurrent ulcers is 1 gram twice daily.

DRUG INTERACTIONS: When administered with other drugs sucralfate may bind to the drugs in the stomach and reduce absorption of the drugs. Sucralfate reduces the absorption of cimetidine (Tagamet), digoxin (Lanoxin), ketoconazole (Nizoral), levothyroxine (Synthroid), phenytoin (Dilantin), quinidine (Quinidex, Quinaglute), ranitidine (Zantac), tetracycline, theophylline (Theo-Dur, Uniphyl, others), and all of the fluoroquinolone antibiotics, including ciprofloxacin (Cipro), norfloxacin (Noroxin), ofloxacin (Floxin), and lomefloxacin (Maxaquin). All of these medications should be taken at least two hours prior to the sucralfate.

It is possible, if not likely, that many other drugs will interact similarly with sucralfate. Therefore, it probably is prudent to take all medications at least 2 hours prior to sucralfate.

PREGNANCY: Sucralfate itself is not teratogenic (causing congenital deformities) in animals, even in doses considerably higher than those used in humans. Although some animal data demonstrate concern for the effects of aluminum during pregnancy, all human data show no ill-effect on the fetus. Sucralfate is considered safe during pregnancy.

NURSING MOTHERS: Minimal if any sucralfate penetrates into breast milk because so little is absorbed from the gastrointestinal tract. Although there are no data, sucralfate is considered safe in nursing mothers.



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