Streptococcal Infections (cont.)

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What complications are seen with group A streptococcal infections?

Many of the complications of GAS infections are considered to be diseases themselves. For example, scarlet fever, rheumatic fever, necrotizing fasciitis, toxic shock syndrome, and many others can complicate or be triggered by GAS infection. Other complications can include the necessity to remove tonsils, renal damage, abscess formation, seizures, and other organ damage; some researchers suggest that severe GAS infections in children may lead to permanent or long-lasting brain changes.

Can group A streptococcal infections be prevented?

Many GAS infections can be prevented by reducing the spread of organisms from one person to another. Washing hands frequently is one of the major ways to reduce bacterial transmission. In addition, not sharing the same food and drink containers with others may also be effective. For those people with a GAS infection, covering the mouth and nose when sneezing or coughing can reduce the chance of transmitting the bacteria to others. Washing material that comes in contact with GAS-infected people is also another way to reduce exposure to GAS organisms.

Early treatment of deep infections (for example, excision, drainage, and antibiotic treatment of rectal abscesses) helps prevent invasive GAS disease. In addition, appropriate and timely removal of tampons and surgical packing may reduce the incidence of toxic shock syndrome.

Currently, there is no vaccine commercially available for GAS, but researchers are working on developing vaccines. At least four different major approaches are being researched. There has been some success with a related experimental vaccine against GAS bacterial antigens coupled to cholera toxin subunits. However, the GAS vaccine, prepared by recombinant technology by Vaxent, a vaccine company, may be going into human clinical trials. The new experimental vaccines may become available in the future to prevent GAS infections.

Medically Reviewed by a Doctor on 10/16/2014

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