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- Patient Comments: Stiff-Person Syndrome - Symptoms
- Patient Comments: Stiff-Person Syndrome - Diagnosis
- Patient Comments: Stiff-Person Syndrome - Treatment
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- What is Stiff-Person syndrome?
- What are the signs and symptoms of Stiff-Person syndrome?
- Who is affected by, and what causes Stiff-Person syndrome?
- How is Stiff-Person syndrome diagnosed?
- Is there any treatment for Stiff-Person syndrome?
- What is the prognosis for Stiff-Person syndrome?
- What research is being done for Stiff-Person syndrome?
Is there any treatment for Stiff-Person syndrome?
People with Stiff-Person syndrome respond to high doses of diazepam and several anti-convulsants, gabapentin and tiagabine. A study funded by the NINDS demonstrated the effectiveness of intravenous immunoglobulin (IVIg) treatment in reducing stiffness and lowering sensitivity to noise, touch, and stress in people with Stiff-Person syndrome.
What is the prognosis for Stiff-Person syndrome?
Treatment with IVIg, anti-anxiety drugs, muscle relaxants, anti-convulsants, and pain relievers will improve the symptoms of Stiff-Person syndrome, but will not cure the disorder. Most individuals with Stiff-Person syndrome have frequent falls and because they lack the normal defensive reflexes; injuries can be severe. With appropriate treatment, the symptoms are usually well controlled.
What research is being done for Stiff-Person syndrome?
The National Institute of Neurological Disorders and Stroke (NINDS) conducts research related to Stiff-Person syndrome in its laboratories at the National Institutes of Health (NIH), and also supports additional research through grants to major medical institutions across the country. A study using the drug rituximab proved ineffective in treating individuals with the disorder. Current research is focused on understanding the cause of the disease and the role of the anti-GAD antibodies.
Medically reviewed by Jon Glass, MD; American board of Psychiatry and Neurology
Last update: 11/15/2010
SOURCE: NINDS.gov. Stiff-Person Syndrome.