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February 10, 2012
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st. john's wort (hypericum perforatum) - oral

GENERIC NAME: ST. JOHN'S WORT (Hypericum perforatum) - ORAL

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: St. John's wort has been used for depression.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details.

HOW TO USE: Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist. Do not take more than the recommended amount. It may take about 3 weeks of regular use before you notice the benefits of this product.Do not suddenly stop taking this product. Some conditions may become worse when this product is abruptly stopped. You may need to gradually reduce your dose. Consult your doctor or pharmacist for details.If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

SIDE EFFECTS: Trouble sleeping, restlessness, upset stomach, dizziness, headache, or numbness/tingling of the hands/feet may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.Tell your doctor immediately if this unlikely but serious side effect occurs: a sunburn-like skin reaction (increased sun sensitivity).Tell your doctor immediately if any of these rare but very serious side effects occur: black/bloody/tarry stools, vomit that looks like coffee grounds, easy bruising/bleeding.This product may rarely cause a very serious condition called serotonin syndrome. The risk increases when this product is used with certain drugs such as "triptans" used to treat migraine headaches (e.g., sumatriptan, eletriptan), certain antidepressants including SSRIs (e.g., citalopram, paroxetine) and SNRIs (e.g., duloxetine, venlafaxine), lithium, tramadol, tryptophan, or a certain drug to treat obesity (sibutramine). See also Drug Interactions section. Before taking this product, tell your doctor if you take any of these medications. Serotonin syndrome may be more likely when you start or increase the dose of any of these medications. Seek immediate medical attention if you develop any of the following symptoms: unusual mental/mood changes (e.g., strange thoughts, unusual excitement, extreme anxiety, confusion), severe dizziness, severe headache, fast heartbeat, unexplained fever, sweating, severe nausea/vomiting/diarrhea, twitching muscles.A very serious allergic reaction to this product is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.




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st. john's wort (hypericum perforatum) - oral

What is a depressive disorder?

Depressive disorders have been with mankind since the beginning of recorded history. In the Bible, King David, as well as Job, suffered from this affliction. Hippocrates referred to depression as melancholia, which literally means black bile. Black bile, along with blood, phlegm, and yellow bile were the four humors (fluids) that described the basic medical physiology theory of that time. Depression, also referred to as clinical depression, has been portrayed in literature and the arts for hundreds of years, but what do we mean today when we refer to a depressive disorder? In the 19th century, depression was seen as an inherited weakness of temperament. In the first half of the 20th century, Freud linked the development of depression to guilt and conflict. John Cheever, the author and a modern sufferer of depressive disorder, wrote of conflict and experiences with his parents as influencing his development of depression.

In the 19...

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