spironolactone, Aldactone (cont.)

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SIDE EFFECTS: Side effects of spironolactone include:

Fluid and electrolytes imbalance (for example, low sodium, low magnesium, and high potassium) may occur, so patients should be monitored carefully. Enlargement of the male breasts (gynecomastia) may also occur and is related to dose and duration of therapy. It usually reverses upon discontinuation of spironolactone.



PREPARATIONS: Tablets: 25, 50, and 100 mg

STORAGE: Spironolactone should be stored at room temperature, below 25 C (77 F).

DOSING: Spironolactone may be taken with or without food. The dosage range is 25-400 mg daily in single or divided doses.

  • The initial dose for treating edema in adults is 100 mg daily as a single dose or divided doses. The dose may be adjusted after 5 days based on response. The recommended dose range is 25 to 200 mg daily. The initial dose should be continued for at least 5 days before increasing the dose. If there is no adequate response after 5 days, a second diuretic may be added.
  • The dose for treating high blood pressure (hypertension) is 50 to 100 mg daily in single or divided doses.
  • The dose for treating hypokalemia is 25 to 100 mg daily.
Medically Reviewed by a Doctor on 4/14/2015

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