Spina Bifida
(Neural Tube Defect)
Introduction to spina bifida
The human nervous system develops from a small, specialized plate of cells
along the back of an embryo. Early in
development, the edges of this plate begin to curl up toward each other,
creating the neural tube—a narrow sheath that closes to form the brain and spinal cord of the
embryo. As development progresses, the top of the tube becomes the brain and the
remainder becomes the spinal cord. This process is usually complete by the 28th
day of pregnancy. But
if problems occur during this process, the result can be brain disorders called
neural tube defects, including spina bifida.
What is spina bifida?
Spina bifida, which literally means "cleft spine," is characterized by the
incomplete development of the brain, spinal cord, and/or meninges (the
protective covering around the brain and spinal cord). It is the most common
neural tube defect in the United States
- affecting 1,500 to 2,000 of the more
than 4 million babies born in the country each year.
What are the different types of spina bifida?
There are four types of spina bifida:
- occulta,
- closed neural tube defects,
- meningocele, and
- myelomeningocele.
Occulta is the mildest and most common form in which one or more vertebrae
are malformed. The name "occulta," which means "hidden," indicates that the
malformation, or opening in the spine, is covered by a layer of skin. This form
of spina bifida rarely causes disability or symptoms.
Closed neural tube defects make up the second type of spina bifida. This form
consists of a diverse group of spinal defects in which the spinal cord is marked
by a malformation of fat, bone, or membranes. In some patients there are few or
no symptoms; in others the malformation causes incomplete paralysis with urinary
and bowel dysfunction.
In the third type, meningocele, the meninges protrude from the spinal
opening, and the malformation may or may not be covered by a layer of skin. Some
patients with meningocele may have few or no symptoms while others may
experience symptoms similar to closed neural tube defects.
Myelomeningocele, the fourth form, is the most severe and occurs when the
spinal cord is exposed through the opening in the spine, resulting in partial or
complete paralysis of the parts of the body below the spinal opening. The
paralysis may be so severe that the affected individual is unable to walk and
may have urinary and bowel dysfunction.
Next: What causes spina bifida? »
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