GENERIC NAME: sonidegib
BRAND NAME: Odomzo
DRUG CLASS AND MECHANISM: Odomzo (sonidegib) is an oral medication used to treat a type of skin cancer called basal cell carcinoma. Sonidegib is an inhibitor of the hedgehog biological signaling pathway, a pathway that promotes the growth of both normal and cancer cells. Sonidegib binds to and inhibits smoothened, a protein involved in hedgehog signaling. Inhibiting smoothened disrupts cell signaling and growth of cancer cells. Sonidegib was approved by the FDA in July, 2015.
PRESCRIBED FOR: Sonidegib is an oral medication used to treat adults with basal cell carcinoma that has recurred following surgery or radiation treatment. It also is used for treating basal cell carcinoma that cannot be treated with surgery or radiation.
SIDE EFFECTS WARNING:
Sonidegib can cause harm to the fetus and should not be used during pregnancy.
- A negative pregnancy test is required before starting sonidegib.
- Females of child bearing potential are advised to use effective forms of birth control (contraception) during treatment and for least 20 months after stopping sonidegib.
- Female patients exposed to sonidegib during pregnancy should report her pregnancy to Novartis Pharmaceuticals Corporation by calling 1-888-669-6682.
- Male patients with female partners are advised to use condoms, even after a vasectomy, during treatment and for at least 8 months after stopping sonidegib.
- Patients should not donate blood or blood products while taking sonidegib and for at least 20 months after stopping because donated blood and blood products may be given to pregnant females or females who can become pregnant, and cause harm to the fetus.
Sonidegib may cause musculoskeletal side effects. Blood creatine kinase (CK) and creatinine levels should be obtained prior to treatment, periodically during treatment, and as needed.
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