- What is sonidegib, and how does it work (mechanism of action)?
- What brand names are available for sonidegib?
- Is sonidegib available as a generic drug?
- Do I need a prescription for sonidegib?
- What are the side effects of sonidegib?
- What is the dosage for sonidegib?
- Which drugs or supplements interact with sonidegib?
- Is sonidegib safe to take if I'm pregnant or breastfeeding?
- What else should I know about sonidegib?
What is sonidegib, and how does it work (mechanism of action)?
Odomzo (sonidegib) is an oral medication used to treat a type of skin cancer called basal cell carcinoma. Sonidegib is an inhibitor of the hedgehog biological signaling pathway, a pathway that promotes the growth of both normal and cancer cells. Sonidegib binds to and inhibits smoothened, a protein involved in hedgehog signaling. Inhibiting smoothened disrupts cell signaling and growth of cancer cells. Sonidegib was approved by the FDA in July, 2015.
PRESCRIBED FOR: Sonidegib is an oral medication used to treat adults with basal cell carcinoma that has recurred following surgery or radiation treatment. It also is used for treating basal cell carcinoma that cannot be treated with surgery or radiation.
What brand names are available for sonidegib?
Is sonidegib available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for sonidegib?
What are the side effects of sonidegib?
The most common side effects of sonidegib include
- hair loss,
- decreased appetite,
- taste changes,
- weight loss,
- stomach pain,
- muscle pain and spasms, and
Women taking sonidegib may experience an absence of menstrual periods (amenorrhea). It is not known if amenorrhea is permanent. Women who wish to get pregnant in the future should talk to their doctor for advice.
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