- What is sofosbuvir, and how does it work?
- What brand names are available for sofosbuvir?
- Is it available as a generic drug?
- Do I need a prescription for it?
- What types of hepatitis C infections does it treat (uses)?
- Sofosbuvir side effects
- How do I use or take sofosbuvir (dosage)?
- Which drugs or supplements interact with sofosbuvir?
- Is it safe to take if I'm pregnant or breastfeeding?
- What else should I know about this drug?
How do I use or take sofosbuvir (dosage)?
The recommended dose of sofosbuvir is one 400 mg tablet once daily with or without food for 12 to 24 weeks.
Which drugs or supplements interact with sofosbuvir?
Rifampin and St. John's wort may reduce blood levels of sofosbuvir by increasing its metabolism (break-down) in the intestine. Therefore, sofosbuvir should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of sofosbuvir include:
- carbamazepine (Tegretol, Tegretol XR
- Equetro, Carbatrol)
- phenytoin (Dilantin, Dilantin-125)
- phenobarbital, oxcarbazepine (Tripetal)
- tipranavir (Aptivus)/ritonavir (Norvir)
Sofosbuvir and amiodarone should not be combined with another direct-acting antiviral agent because combining them may significantly reduce heart rate, especially in people who are taking beta-blockers or have underlying heart problems.
Quick GuideHepatitis C (Hep C) Symptoms and Treatment
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