How do I use or take sofosbuvir (dosage)?
The recommended dose of sofosbuvir is one 400 mg tablet once daily with or without food for 12 to 24 weeks.
Which drugs or supplements interact with sofosbuvir?
Rifampin and St. John's wort may reduce blood levels of sofosbuvir by increasing its metabolism (break-down) in the intestine. Therefore, sofosbuvir should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of sofosbuvir include:
- carbamazepine (Tegretol, Tegretol XR
- Equetro, Carbatrol)
- phenytoin (Dilantin, Dilantin-125)
- phenobarbital, oxcarbazepine (Tripetal)
- tipranavir (Aptivus)/ritonavir (Norvir)
Sofosbuvir and amiodarone should not be combined with another direct-acting antiviral agent because combining them may significantly reduce heart rate, especially in people who are taking beta-blockers or have underlying heart problems.
Is it safe to take if I'm pregnant or breastfeeding?
- There hasn't been enough research and evaluation of sofosbuvir in pregnant women. However, ribavirin, which is combined with sofosbuvir should not be used if you're pregnant. Your male partner shouldn't use it either.
- Researchers don't know if sofosbuvir is secreted into breast milk.
What else should I know about this drug?
- This drug is available in 400 mg tablets.
- Keep the tablets stored at room temperature below 30 C (86 F).
- The FDA approved Sovaldi in December 2013.
Reference: FDA Prescribing Information
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