sofosbuvir (Sovaldi)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is sofosbuvir, and how does it work?

  • Sofosbuvir is an oral, direct-acting antiviral agent used for treating infections with the hepatitis C virus (HCV).
  • Other direct-acting hepatitis C treatments include:
  • After administration sofosbuvir is first converted to an active form. The active form of sofosbuvir interferes with multiplication of the ribonucleic acid (RNA) of HCV leading to reduced numbers of hepatitis C virus in the body.
  • Sofosbuvir is effective for treating infection with HCV genotype 1,2,3, or 4, and in clinical trials, 50% to 90% of individuals treated with the drug cleared the hepatitis C virus from their blood.

What brand names are available for sofosbuvir?

Sovaldi is the brand name available for this drug in the US.

Is it available as a generic drug?

No, there's no generic available.

Do I need a prescription for it?

Yes, you need a prescription from your doctor or health care professional for this drug.

What types of hepatitis C infections does it treat (uses)?

Sofosbuvir is used in combination with ribavirin (Rebetol, Copegus) or ribavirin plus interferon to treat hepatitis C virus (HCV) genotypes 1, 2, 3, or 4 infection.

Sofosbuvir side effects

The most common side effects reported by patients include:

Other side effects include:

Medically Reviewed by a Doctor on 3/2/2017

Quick GuideHepatitis C (Hep C) Symptoms and Treatment

Hepatitis C (Hep C) Symptoms and Treatment
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