sofosbuvir, Sovaldi

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: sofosbuvir

BRAND NAME: Sovaldi

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

USES: Sofosbuvir is used in combination with ribavirin (Rebetol, Copegus) or ribavirin plus interferon to treat HCV.

SIDE EFFECTS: The most common side effects associated with sofosbuvir treatment are:

Other side effect include:

PREPARATIONS: Tablets: 400 mg

DRUG INTERACTIONS: Rifampin and St. John's wort may reduce blood levels of sofosbuvir by increasing its metabolism (break-down) in the intestine. Therefore, sofosbuvir should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of sofosbuvir include carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol), phenytoin (Dilantin, Dilantin-125), phenobarbital, oxcarbazepine (Tripetal), rifabutin, rifampin, rifapentine, and tipranavir (Aptivus)/ritonavir (Norvir).

Medically Reviewed by a Doctor on 1/22/2016

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