sofosbuvir, Sovaldi

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GENERIC NAME: sofosbuvir


DRUG CLASS AND MECHANISM: Sofosbuvir is an oral, direct-acting antiviral agent used for treating infections with the hepatitis C virus (HCV). Boceprevir (Victrelis), telaprevir (Incivek), and simeprevir (Olysio) are other direct-acting HCV treatments. After administration sofosbuvir is first converted to an active form. The active form of sofosbuvir interferes with multiplication of the ribonucleic acid (RNA) of HCV leading to reduced numbers of HCV in the body. Sofosbuvir is effective for treating infection with HCV genotype 1,2,3, or 4, and in clinical trials, 50% to 90% of individuals treated with sofosbuvir cleared HCV from their blood. The FDA approved Sovaldi in December 2013.

Medically Reviewed by a Doctor on 1/23/2014

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