sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex, SP) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Sodium polystyrene sulfonate may decrease the absorption of lithium (Eskalith, Lithobid).

Sodium polystyrene sulfonate may decrease the absorption of thyroxine or levothyroxine (Synthroid). Therefore, the administration of thyroid hormones and sodium polystyrene sulfonate should be separated by at least 4 hours.

PREGNANCY: Sodium polystyrene sulfonate is classified asFDA pregnancy risk category C. Use of sodium polystyrene sulfonate during pregnancy has not be adequately studied. Due to the lack of conclusive safety data, sodium polystyrene sulfonate should only be used during pregnancy if the benefits of treatment outweigh the potential risk to the fetus.

NURSING MOTHERS: It is not known if sodium polystyrene sulfonate is excreted in human milk. Due to the lack of safety data, this medication should be used cautiously in females who are breastfeeding.

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 12/15/2014


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