sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex, SP)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Concomitant use of sorbitol (Ora-Blend, Ora-Blend SF, Numoisyn Lozenges, Saliva Substitute) with sodium polystyrene sulfonate may cause colonic necrosis. Therefore, use of this combination treatment is not recommended.

Sodium polystyrene sulfonate may decrease the absorption of lithium (Eskalith, Lithobid).

Sodium polystyrene sulfonate may decrease the absorption of thyroxine or levothyroxine (Synthroid). Therefore, the administration of thyroid hormones and sodium polystyrene sulfonate should be separated by at least 4 hours.

PREGNANCY: Sodium polystyrene sulfonate is classified asFDA pregnancy risk category C. Use of sodium polystyrene sulfonate during pregnancy has not be adequately studied. Due to the lack of conclusive safety data, sodium polystyrene sulfonate should only be used during pregnancy if the benefits of treatment outweigh the potential risk to the fetus.

NURSING MOTHERS: It is not known if sodium polystyrene sulfonate is excreted in human milk. Due to the lack of safety data, this medication should be used cautiously in females who are breastfeeding.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 12/15/2014
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