sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex, SP) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Large oral doses have been reported to cause fecal impaction in the elderly, while large rectal doses have caused fecal impaction in children.
Colonic necrosis is one of the most serious side effects reported with rectal administration of sodium polystyrene sulfonate.
Rare but serious side effects are:
GENERIC AVAILABLE: Yes
STORAGE: This medication should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
Cation-donating antacids or laxatives may reduce the effectiveness of sodium polystyrene sulfonate when given concomitantly. Examples of cation-donating antacids and laxatives include:
Sodium polystyrene sulfonate should be used cautiously with digoxin (Lanoxin) since sodium polystyrene sulfonate-induced hypokalemia (low blood potassium levels) may increase the risk of cardiac toxicity (heart rhythm abnormalities) associated with digoxin.
Concomitant use of sorbitol (Ora-Blend, Ora-Blend SF, Numoisyn Lozenges, Saliva Substitute) with sodium polystyrene sulfonate may cause colonic necrosis. Therefore, use of this combination treatment is not recommended.
Medically Reviewed by a Doctor on 12/15/2014
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