sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex, SP) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Other side effects include:

Large oral doses have been reported to cause fecal impaction in the elderly, while large rectal doses have caused fecal impaction in children.

Colonic necrosis is one of the most serious side effects reported with rectal administration of sodium polystyrene sulfonate.

Rare but serious side effects are:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Oral suspension: 15 g/60 ml
  • Oral powder for suspension: 454 g
  • Rectal suspension: 15 g/60 ml

STORAGE: This medication should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

DOSING:

  • Oral dosage: Adults: The usual recommended dose is 15 g administered 1 to 4 times per day.
  • Oral dosage: Pediatrics: The usual recommended dose is 1 g/kg administered by mouth every 6 hours as needed.
  • Rectal dosage: Adults: The usual recommended dose is 30 to 50 g administered rectally every 1-2 hours initially, followed by repeat doses every 6 hours if needed.
  • Rectal dosage: Pediatrics: The usual recommended dose is 1 g/kg administered rectally every 6 hours as needed.

DRUG INTERACTIONS:

Cation-donating antacids or laxatives may reduce the effectiveness of sodium polystyrene sulfonate when given concomitantly. Examples of cation-donating antacids and laxatives include:

Medically Reviewed by a Doctor on 12/15/2014


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