sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex, SP)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for sodium polystyrene sulfonate-powder?

  • Oral dosage Adults: The usual recommended dose is 15 g administered 1 to 4 times per day.
  • Oral dosage Pediatrics: The usual recommended dose is 1 g/kg administered by mouth every 6 hours as needed.
  • Rectal dosage Adults: The usual recommended dose is 30 to 50 g administered rectally every 1-2 hours initially, followed by repeat doses every 6 hours if needed.
  • Rectal dosage Pediatrics: The usual recommended dose is 1 g/kg administered rectally every 6 hours as needed.

Which drugs or supplements interact with sodium polystyrene sulfonate-powder?

Cation-donating antacids or laxatives may reduce the effectiveness of sodium polystyrene sulfonate when given concomitantly. Examples of cation-donating antacids and laxatives include:

Sodium polystyrene sulfonate should be used cautiously with digoxin (Lanoxin) since sodium polystyrene sulfonate-induced hypokalemia (low blood potassium levels) may increase the risk of cardiac toxicity (heart rhythm abnormalities) associated with digoxin.

Concomitant use of sorbitol (Ora-Blend, Ora-Blend SF, Numoisyn Lozenges, Saliva Substitute) with sodium polystyrene sulfonate may cause colonic necrosis. Therefore, use of this combination treatment is not recommended.

Sodium polystyrene sulfonate may decrease the absorption of lithium (Eskalith, Lithobid).

Sodium polystyrene sulfonate may decrease the absorption of thyroxine or levothyroxine (Synthroid). Therefore, the administration of thyroid hormones and sodium polystyrene sulfonate should be separated by at least 4 hours.

Medically Reviewed by a Doctor on 5/16/2017
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