Rare but serious side effects are:
- acute bronchitis (related to inhalation of powder),
- gastrointestinal bleeding,
- gastrointestinal ulceration,
- intestinal perforation, and
- ischemic colitis.
GENERIC AVAILABLE: Yes
- Oral suspension: 15 g/60 ml
- Oral powder for suspension: 454 g
- Rectal suspension: 15 g/60 ml
STORAGE: This medication should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
- Oral dosage: Adults: The usual recommended dose is 15 g administered 1 to 4 times per day.
- Oral dosage: Pediatrics: The usual recommended dose is 1 g/kg administered by mouth every 6 hours as needed.
- Rectal dosage: Adults: The usual recommended dose is 30 to 50 g administered rectally every 1-2 hours initially, followed by repeat doses every 6 hours if needed.
- Rectal dosage: Pediatrics: The usual recommended dose is 1 g/kg administered rectally every 6 hours as needed.
Cation-donating antacids or laxatives may reduce the effectiveness of sodium polystyrene sulfonate when given concomitantly. Examples of cation-donating antacids and laxatives include:
- aluminum hydroxide,
- calcium carbonate (Caltrate 600, Os-Cal 500, Tums Extra, Tums Chewy Delight, and Many Others),
- magnesium carbonate,
- magnesium citrate, and
- magnesium hydroxide.
Sodium polystyrene sulfonate should be used cautiously with digoxin (Lanoxin) since sodium polystyrene sulfonate-induced hypokalemia (low blood potassium levels) may increase the risk of cardiac toxicity (heart rhythm abnormalities) associated with digoxin.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.