sodium iodide I 131, Iodotope, Sodium Iodide I 131 Therapeutic (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
STORAGE: Sodium iodide I 131 should be store at room temperature, 20-25 C (68-77 C). Sodium iodide I 131 is ordered for individual patients in a hospital setting. It arrives at room temperature in a lead container to minimize radiation exposure to hospital personnel. Special handling is required.
PRESCRIBED FOR: Sodium iodide I 131 is used to treat hyperthyroidism and some cases of thyroid cancer.
DOSING: The usual sodium iodide I 131 dose ranges from 4-10 mCi to treat hyperthyroidism. Doses to treat thyroid cancer are individualized and are usually 10-27 times greater than for hyperthyroidism.
DRUG INTERACTIONS: Non-radioactive iodine, thyroid hormone, propylthiouracil (PTU) or methimazole (Tapazole, Northyx) may all interfere with the trapping of sodium iodide I 131 by the thyroid gland. Thyroid hormone, drugs that contain iodine (for example, amiodarone [Coradone]), and iodine containing contrast agents all interfere with the action of sodium iodide I 131.
PREGNANCY: Sodium iodide I 131 has been shown to cause harm to a developing fetus. Use in pregnant women should be avoided.
NURSING MOTHERS: Iodine is excreted in breast milk. Therefore, formula feedings for infants are strongly recommended for nursing women requiring sodium iodide I 131 treatment.
SIDE EFFECTS: The side effects commonly seen with sodium iodide I 131 treatment are mild with the smaller doses given for hyperthyroidism but may be more severe with the larger doses given for thyroid cancer. Sodium iodide I 131 may cause suppression of the bone marrow, resulting in anemia, and reductions in white blood cells and platelets. It also may cause acute leukemia.
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