- What is sodium iodide I 131, and how does it work (mechanism of action)?
- What brand names are available for sodium iodide I 131?
- Is sodium iodide I 131 available as a generic drug?
- Do I need a prescription for sodium iodide I 131?
- What are the side effects of sodium iodide I 131?
- What is the dosage for sodium iodide I 131?
- Which drugs or supplements interact with sodium iodide I 131?
- Is sodium iodide I 131 safe to take if I'm pregnant or breastfeeding?
- What else should I know about sodium iodide I 131?
What is sodium iodide I 131, and how does it work (mechanism of action)?
Sodium iodide I 131 is an oral medication used to treat hyperthyroidism (overactive thyroid gland) and some cases of thyroid cancer. It falls under the category of an anti-thyroid drug but differs from the other anti-thyroid drugs, propylthiouracil (PTU) and methimazole (Tapazole), because it is radioactive. Sodium iodide I 131 is taken by mouth, readily absorbed into the body and is trapped within the thyroid gland. The trapped sodium iodide I 131 irradiates the thyroid gland thereby damaging it. As a result, the activity of the thyroid gland (that is, the production and release of thyroid hormone) is reduced. Excess sodium iodide I 131 is eliminated from the body in the urine by the kidneys. The sodium iodide retained in the body loses most of its radioactivity over several weeks. The half-life of the radioactivity is eight days. The FDA approved sodium iodide I 131 in August 1971.
What brand names are available for sodium iodide I 131?
Sodium Iodide I 131 Therapeutic, Hicon
Is sodium iodide I 131 available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for sodium iodide I 131?
What are the side effects of sodium iodide I 131?
The side effects commonly seen with sodium iodide I 131 treatment are mild with the smaller doses given for hyperthyroidism but may be more severe with the larger doses given for thyroid cancer. Sodium iodide I 131 may cause suppression of the bone marrow, resulting in anemia, and reductions in white blood cells and platelets. It also may cause acute leukemia.
Other important side effects that can occur with large doses include symptoms of:
Thyroid crisis (due to the release of large amounts of thyroid hormone), severe inflammation of the salivary glands, and chromosomal abnormalities may occur. On day three after treatment, a constellation of signs and symptoms may occur including:
Finally, temporary hair thinning may occur two to three months after treatment.
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