sodium chloride solution (intravenous) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Use of tolvaptan (Samsca) with hypertonic preparations of sodium chloride (3% or 5% solution for injection) is not recommended as rapid correction of hyponatremia (low levels of sodium in the blood) increases the risk of osmotic demyelination (nerve damage).

PREGNANCY: It is not known if sodium chloride can cause harm to unborn baby. However, 0.9% sodium chloride (normal saline or NS) has been administered to pregnant women without any reports of harm. The manufacturer recommends that sodium chloride should only be administered to pregnant women if clearly needed. Sodium chloride is classified as FDA pregnancy risk category C (Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.).

NURSING MOTHERS: It is not known if sodium chloride is excreted into human milk. As 0.9% sodium chloride solution has the same osmotic pressure as that in the serum, risk of adverse effects with its use during breastfeeding is considered minimal. However, sodium chloride bacteriostatic injection should be used cautiously in nursing mothers as the benzyl alcohol preservative found in the solution has been found to cause adverse events in the nursing infant.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 5/12/2015

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