sodium chloride solution (intravenous) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Side effects associated with use of intravenous sodium chloride include:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Sodium chloride diluent for injection: 0.9%
  • Sodium chloride solution for injection: 0.9% prefilled syringe, normal saline flush 0.9% solution, sodium chloride 0.45% solution (1/2 NS), sodium chloride hypertonic 3% solution, sodium chloride hypertonic 5% solution.

STORAGE: Sodium chloride preparations should be stored at room temperature between 59 F to 86 F (15 C to 30 C).

DOSING: Dosing of sodium chloride intravenous solution varies. Total volume of administration depends on many factors including condition being treated, laboratory results, and other patient specific characteristics.

Systemic administration of sodium chloride solution should be done with extreme caution as rapid or overt administration may cause complications such as:

  • fluid overload,
  • pulmonary edema (water in the lungs),
  • cell damage,
  • severe electrolyte abnormalities,
  • brain damage, and
  • intraventricular hemorrhage.

DRUG INTERACTIONS:

Although use of sodium chloride solution has not been associated with any serious or life threatening drug interactions, unintended increases in sodium and water retention may occur when used with corticosteroids.

Use of sodium chloride intravenous solution may increase the renal elimination of lithium (Eskalith, Lithobid). Lithium concentrations and control of symptoms should be monitored frequently in patients receiving IV sodium chloride.

Use of tolvaptan (Samsca) with hypertonic preparations of sodium chloride (3% or 5% solution for injection) is not recommended as rapid correction of hyponatremia (low levels of sodium in the blood) increases the risk of osmotic demyelination (nerve damage).

Medically Reviewed by a Doctor on 5/12/2015


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