sodium chloride solution (intravenous) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Side effects associated with use of intravenous sodium chloride include:

  • hypernatremia (high levels of sodium),
  • fluid retention,
  • high blood pressure,
  • heart failure,
  • intraventricular hemorrhage in neonates,
  • injection site reactions,
  • kidney damage,
  • electrolyte abnormalities, and
  • others.




  • Sodium chloride diluent for injection: 0.9%
  • Sodium chloride solution for injection: 0.9% prefilled syringe, normal saline flush 0.9% solution, sodium chloride 0.45% solution (1/2 NS), sodium chloride hypertonic 3% solution, sodium chloride hypertonic 5% solution.

STORAGE: Sodium chloride preparations should be stored at room temperature between 59 F to 86 F (15 C to 30 C).

DOSING: Dosing of sodium chloride intravenous solution varies. Total volume of administration depends on many factors including condition being treated, laboratory results, and other patient specific characteristics.

Systemic administration of sodium chloride solution should be done with extreme caution as rapid or overt administration may cause complications such as:


Although use of sodium chloride solution has not been associated with any serious or life threatening drug interactions, unintended increases in sodium and water retention may occur when used with corticosteroids.

Use of sodium chloride intravenous solution may increase the renal elimination of lithium (Eskalith, Lithobid). Lithium concentrations and control of symptoms should be monitored frequently in patients receiving IV sodium chloride.

Medically Reviewed by a Doctor on 5/12/2015

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index